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• W4319706196 endingPage "6363" @default.
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• W4319706196 abstract "By combining single-channel and whole-cell patch-clamp recordings, we have established the sensitivity to ω-agatoxin IVA and ω-conotoxin MVIIC (SNX-230) of G1, G2, and G3, the three novel non-L-, non-N-type Ca 2+ channels characterized previously in rat cerebellar granule cells. G1 channels were blocked irreversibly by both ω-conotoxin MVIIC and low doses of ω-agatoxin IVA (saturation at 50 n m ). Thus, according to pharmacological criteria, G1 channels must be classified as P-type Ca 2+ channels. Being slowly inactivating during depolarizing pulses and completely inactivated at voltages in which steady-state inactivation of P-type channels in Purkinje cells is negligible, G1 represents a novel P subtype. Neither G2 nor G3 was blocked irreversibly by ω-conotoxin MVIIC, and therefore both are R-type Ca 2+ channels. G2 and G3 have some biophysical properties similar to those of low-voltage-activated (LVA) Ca 2+ channels (e.g., voltage range for steady-state inactivation, V 1/2 = −90 mV), some properties similar to those of high-voltage-activated (HVA) Ca 2+ channels (e.g., high sensitivity to Cd 2+ block), and other properties intermediate between those of LVA and HVA Ca 2+ channels, with LVA properties prevailing in G2 and HVA properties prevailing in G3. The R-type whole-cell current was inhibited by Ni 2+ with a biphasic dose–response curve (IC 50 : 4 and 153 μ m ), suggesting that G2 and G3 may have a different sensitivity to Ni 2+ block. Our results uncover functional diversity of both native P-type and R-type Ca 2+ channels and show that R subtypes with distinct biophysical properties are coexpressed in rat cerebellar granule cells." @default.
• W4319706196 created "2023-02-10" @default.
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• W4319706196 date "1996-10-15" @default.
• W4319706196 modified "2023-09-30" @default.
• W4319706196 title "Functional Diversity of P-Type and R-Type Calcium Channels in Rat Cerebellar Neurons" @default.
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• W4319706196 doi "https://doi.org/10.1523/jneurosci.16-20-06353.1996" @default.
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