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- W4319734859 abstract "Disulfide bond formation is fundamentally important for protein structure, and constitutes a key mechanism by which cells regulate the intracellular oxidation state. Peroxiredoxins (PRDXs) eliminate reactive oxygen species such as hydrogen peroxide by using a catalytic cycle of Cys oxidation and reduction. High molecular-weight assemblies of PRDXs have recently been shown to additionally act as molecular chaperones. The consequences of disulfide bonds on the dynamics of these large assemblies are poorly understood. We show that formation of disulfide bonds along the catalytic cycle induces extensive μs time scale dynamics, as monitored by magic-angle spinning NMR of the 216 kDa-large Tsa1 decameric assembly and solution-NMR of a designed dimeric mutant. We ascribe the conformational dynamics to structural frustration, resulting from conflicts between the disulfide-constrained reduction of mobility and the desire to fulfil other favorable contacts." @default.
- W4319734859 created "2023-02-11" @default.
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- W4319734859 creator A5069462831 @default.
- W4319734859 date "2023-02-09" @default.
- W4319734859 modified "2023-10-18" @default.
- W4319734859 title "Disulfide-bond-induced structural frustration and dynamic disorder in a peroxiredoxin from MAS NMR" @default.
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- W4319734859 doi "https://doi.org/10.1101/2023.02.08.527717" @default.
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