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- W4319736414 abstract "Influenza A virus (IAV) is one of the most important primary agents in porcine respiratory disease complex (PRDC). The gene expression profile was evaluated by RNA-Seq analysis in mediastinal lymph nodes from non-vaccinated and vaccinated pigs with a nanovaccine for IAV to clarify molecular mechanisms and genes involved in the protective immunity conferred by influenza vaccination. A total of 14,381 genes were expressed in the analysed tissue. From those, 564 were differentially expressed (DE) between the two groups. Eighteen biological processes (BP) were enriched in immune response, cell cycle regulation and reproductive processes. The defence response was the BP with more gene counts, including chemokines (CXCL9, CXCL10, CCL8, CXCL8), interleukin (IL21, IL26), interferons (ISG20, IFN-alpha-8), within others. The transcriptome analyses provided a better understanding of the immunogenicity in pigs induced by nanovaccination and could support the development and evaluation of better vaccines for swine and other animal species." @default.
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- W4319736414 date "2022-12-31" @default.
- W4319736414 modified "2023-10-18" @default.
- W4319736414 title "153. Molecular mechanisms involved with influenza A nanovaccine immunogenicity in pigs" @default.
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- W4319736414 doi "https://doi.org/10.3920/978-90-8686-940-4_153" @default.
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