Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319745906> ?p ?o ?g. }
- W4319745906 abstract "The rise in antimicrobial resistance and the decline in new antibiotics has created a great need for novel approaches to treat drug resistant bacterial infections. Increasing the burden of antimicrobial resistance, bacterial virulence factors allow for survival within the host, where they can evade host killing and antimicrobial therapy within their intracellular niches. Repurposing host directed therapeutics has great potential for adjuvants to allow for more effective bacterial killing by the host and antimicrobials. To this end, phosphoinositide 3-kinase inhibitors are FDA approved for cancer therapy, but also have potential to eliminate intracellular survival of pathogens. This review describes the PI3K pathway and its potential as an adjuvant target to treat bacterial infections more effectively." @default.
- W4319745906 created "2023-02-11" @default.
- W4319745906 creator A5005992045 @default.
- W4319745906 date "2023-02-09" @default.
- W4319745906 modified "2023-10-05" @default.
- W4319745906 title "Repurposing inhibitors of phosphoinositide 3-kinase as adjuvant therapeutics for bacterial infections" @default.
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