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- W4319751152 abstract "Tumor evolution to evade immune surveillance is a hallmark of carcinogenesis, and the modulation of tumor immunogenicity has been a challenge to present therapeutic responses in immunotherapies alone for numerous cancers. By altering the cell phenotype and reshaping the tumor microenvironment, epigenetic modifications enable tumor cells to overcome immune surveillance as a mechanism of cancer progression and immunotherapy resistance. Demethylase enzymatic activity of lysine-specific demethylase 1 (LSD1), a histone demethylase first identified in 2004, plays a pivotal role in the vast cellular processes of cancer. While FDA-approved indications for epigenetic therapies are limited to hematological malignancies, it is imperative to understand how epigenetic machinery can be targeted to prime immunotherapy responses in breast cancers. In this review, we discuss the potential roles of epigenetics and demethylating agent LSD1 as a potent new cancer management strategy to combat the current challenges of breast cancers, which have presented modest efficacy to immune checkpoint inhibitors till date. Additionally, we describe the combined use of LSD1-specific inhibitors and immune checkpoint inhibitors in existing breast cancer preclinical and clinical trials that elicits a robust immune response and benefit. Overall, the promising results observed in LSD1-targeting therapies signify the central role of epigenetics as a potential novel strategy to overcome resistance commonly seen in immunotherapies." @default.
- W4319751152 created "2023-02-11" @default.
- W4319751152 creator A5017536914 @default.
- W4319751152 creator A5045019048 @default.
- W4319751152 creator A5077825299 @default.
- W4319751152 date "2023-02-09" @default.
- W4319751152 modified "2023-10-01" @default.
- W4319751152 title "Lysine-Specific Demethylase 1 (LSD1)-Mediated Epigenetic Modification of Immunogenicity and Immunomodulatory Effects in Breast Cancers" @default.
- W4319751152 cites W1566018542 @default.
- W4319751152 cites W1953890763 @default.
- W4319751152 cites W1964813856 @default.
- W4319751152 cites W1965027943 @default.
- W4319751152 cites W1965862088 @default.
- W4319751152 cites W1966644185 @default.
- W4319751152 cites W1970250447 @default.
- W4319751152 cites W1980673831 @default.
- W4319751152 cites W1985159629 @default.
- W4319751152 cites W1985905844 @default.
- W4319751152 cites W2003152268 @default.
- W4319751152 cites W2003891642 @default.
- W4319751152 cites W2013785611 @default.
- W4319751152 cites W2020414099 @default.
- W4319751152 cites W2030908446 @default.
- W4319751152 cites W2035895762 @default.
- W4319751152 cites W2037610638 @default.
- W4319751152 cites W2040365591 @default.
- W4319751152 cites W2046509449 @default.
- W4319751152 cites W2054621094 @default.
- W4319751152 cites W2074239511 @default.
- W4319751152 cites W2088029302 @default.
- W4319751152 cites W2088260828 @default.
- W4319751152 cites W2092282705 @default.
- W4319751152 cites W2096083625 @default.
- W4319751152 cites W2104209180 @default.
- W4319751152 cites W2106747061 @default.
- W4319751152 cites W2114892231 @default.
- W4319751152 cites W2121417064 @default.
- W4319751152 cites W2134127468 @default.
- W4319751152 cites W2137915568 @default.
- W4319751152 cites W2139077902 @default.
- W4319751152 cites W2140252793 @default.
- W4319751152 cites W2142303705 @default.
- W4319751152 cites W2148383862 @default.
- W4319751152 cites W2157232603 @default.
- W4319751152 cites W2158630016 @default.
- W4319751152 cites W2162951729 @default.
- W4319751152 cites W2172085202 @default.
- W4319751152 cites W2185365717 @default.
- W4319751152 cites W2324313493 @default.
- W4319751152 cites W2341775915 @default.
- W4319751152 cites W2407406252 @default.
- W4319751152 cites W2412507621 @default.
- W4319751152 cites W2469758901 @default.
- W4319751152 cites W2499896871 @default.
- W4319751152 cites W2502545577 @default.
- W4319751152 cites W2507949874 @default.
- W4319751152 cites W2536817740 @default.
- W4319751152 cites W2541574334 @default.
- W4319751152 cites W2552680036 @default.
- W4319751152 cites W2554954289 @default.
- W4319751152 cites W2586020508 @default.
- W4319751152 cites W2587048937 @default.
- W4319751152 cites W2592935721 @default.
- W4319751152 cites W2604667388 @default.
- W4319751152 cites W2605077517 @default.
- W4319751152 cites W2729462249 @default.
- W4319751152 cites W2734546988 @default.
- W4319751152 cites W2736147637 @default.
- W4319751152 cites W2738161330 @default.
- W4319751152 cites W2741646268 @default.
- W4319751152 cites W2744988474 @default.
- W4319751152 cites W2761177724 @default.
- W4319751152 cites W2762828108 @default.
- W4319751152 cites W2774935716 @default.
- W4319751152 cites W2782309226 @default.
- W4319751152 cites W2792566263 @default.
- W4319751152 cites W2808090480 @default.
- W4319751152 cites W2809237949 @default.
- W4319751152 cites W2810896552 @default.
- W4319751152 cites W2885441485 @default.
- W4319751152 cites W2887577080 @default.
- W4319751152 cites W2890606163 @default.
- W4319751152 cites W2914335731 @default.
- W4319751152 cites W2961584252 @default.
- W4319751152 cites W2969727479 @default.
- W4319751152 cites W2980582006 @default.
- W4319751152 cites W2989811984 @default.
- W4319751152 cites W2990500323 @default.
- W4319751152 cites W2993378407 @default.
- W4319751152 cites W3011810360 @default.
- W4319751152 cites W3015068997 @default.
- W4319751152 cites W3016998599 @default.
- W4319751152 cites W3028082975 @default.
- W4319751152 cites W3034433055 @default.
- W4319751152 cites W3039614857 @default.
- W4319751152 cites W3039724956 @default.
- W4319751152 cites W3049750006 @default.
- W4319751152 cites W3096958321 @default.