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- W4319751432 abstract "We have designed and synthesized a unique library of benzylidene-6-(5-chloropyrimidin-2-yl)-9H-purine-2,6- diamine derivatives as angiogenesis inhibitors. The designed scaffolds were subjected to docking and ADME prediction studies so as to guage the particular interaction. Further anti-proliferative activity was allotted by employing the SRB method as a target for colorectal cancer on HT-29 and COLO-205 cell lines. The SM-6 derivative showed good anticancer activity and was subjected to in-vitro enzyme inhibition activity using a flow cytometer to test the enzyme inhibition potential. It also induced apoptosis and cell cycle arrest at the G0/G1 phase on HT-29 cells supported by DAPI staining and propidium iodide (PI) staining followed by flow cytometry analyses. These compounds exhibited slight inhibitory effects against VEGFR and c-Met kinases, so their active skeletons warrant further study and will have a positive effect on the event of small anticancer inhibitors of dual-target VEGFR/c-Met kinase." @default.
- W4319751432 created "2023-02-11" @default.
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- W4319751432 date "2022-01-01" @default.
- W4319751432 modified "2023-09-26" @default.
- W4319751432 title "DUAL TARGETING OF VEGFR-2 AND C-MET KINASES VIA THE DESIGN AND SYNTHESIS OF SUBSTITUTED BENZYLIDENE-6-(5-CHLOROPYRIMIDIN-2-YL)-9H-PURINE2,6-DIAMINE DERIVATIVES AS ANGIOGENESIS INHIBITORS" @default.
- W4319751432 doi "https://doi.org/10.31788/rjc.2022.1547094" @default.
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