FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319773032> ?p ?o ?g. }

• W4319773032 endingPage "102996" @default.
• W4319773032 startingPage "102996" @default.
• W4319773032 abstract "SOX2 and SOX15 are Sox family transcription factors enriched in embryonic stem cells (ESCs). The role of SOX2 in activating gene expression programs essential for stem cell self-renewal and acquisition of pluripotency during somatic cell reprogramming is well-documented. However, the contribution of SOX15 to these processes is unclear and often presumed redundant with SOX2 largely because overexpression of SOX15 can partially restore self-renewal in SOX2-deficient ESCs. Here, we show that SOX15 contributes to stem cell maintenance by cooperating with ESC-enriched transcriptional coactivators to ensure optimal expression of pluripotency-associated genes. We demonstrate that SOX15 depletion compromises reprogramming of fibroblasts to pluripotency which cannot be compensated by SOX2. Ectopic expression of SOX15 promotes the reversion of a postimplantation, epiblast stem cell state back to a preimplantation, ESC-like identity even though SOX2 is expressed in both cell states. We also uncover a role of SOX15 in lineage specification, by showing that loss of SOX15 leads to defects in commitment of ESCs to neural fates. SOX15 promotes neural differentiation by binding to and activating a previously uncharacterized distal enhancer of a key neurogenic regulator, Hes5. Together, these findings identify a multifaceted role of SOX15 in induction and maintenance of pluripotency and neural differentiation." @default.
• W4319773032 created "2023-02-11" @default.
• W4319773032 creator A5009819814 @default.
• W4319773032 creator A5011571336 @default.
• W4319773032 creator A5013460153 @default.
• W4319773032 creator A5019763760 @default.
• W4319773032 creator A5026118062 @default.
• W4319773032 creator A5026304050 @default.
• W4319773032 creator A5033771596 @default.
• W4319773032 creator A5057462245 @default.
• W4319773032 creator A5064745234 @default.
• W4319773032 creator A5072033621 @default.
• W4319773032 creator A5077972143 @default.
• W4319773032 creator A5087542228 @default.
• W4319773032 date "2023-03-01" @default.
• W4319773032 modified "2023-09-30" @default.
• W4319773032 title "Transcription factor SOX15 regulates stem cell pluripotency and promotes neural fate during differentiation by activating the neurogenic gene Hes5" @default.
• W4319773032 cites W1772859089 @default.
• W4319773032 cites W1921704775 @default.
• W4319773032 cites W1946400262 @default.
• W4319773032 cites W1964224339 @default.
• W4319773032 cites W1974365957 @default.
• W4319773032 cites W1978173381 @default.
• W4319773032 cites W1978560791 @default.
• W4319773032 cites W1985178687 @default.
• W4319773032 cites W1988294855 @default.
• W4319773032 cites W1988913374 @default.
• W4319773032 cites W1989769057 @default.
• W4319773032 cites W1994596013 @default.
• W4319773032 cites W1994859370 @default.
• W4319773032 cites W1996203485 @default.
• W4319773032 cites W1998766660 @default.
• W4319773032 cites W1999275814 @default.
• W4319773032 cites W2004618496 @default.
• W4319773032 cites W2010608530 @default.
• W4319773032 cites W2014677321 @default.
• W4319773032 cites W2019005509 @default.
• W4319773032 cites W2021341670 @default.
• W4319773032 cites W2024892689 @default.
• W4319773032 cites W2028200156 @default.
• W4319773032 cites W2029372290 @default.
• W4319773032 cites W2031005356 @default.
• W4319773032 cites W2031285837 @default.
• W4319773032 cites W2038815755 @default.
• W4319773032 cites W2039839887 @default.
• W4319773032 cites W2048181061 @default.
• W4319773032 cites W2048389644 @default.
• W4319773032 cites W2058255189 @default.
• W4319773032 cites W2058588625 @default.
• W4319773032 cites W2059366905 @default.
• W4319773032 cites W2060613703 @default.
• W4319773032 cites W2061738297 @default.
• W4319773032 cites W2062118486 @default.
• W4319773032 cites W2068780842 @default.
• W4319773032 cites W2069058322 @default.
• W4319773032 cites W2072140342 @default.
• W4319773032 cites W2072859865 @default.
• W4319773032 cites W2074972224 @default.
• W4319773032 cites W2076018308 @default.
• W4319773032 cites W2076612253 @default.
• W4319773032 cites W2078201066 @default.
• W4319773032 cites W2085502970 @default.
• W4319773032 cites W2086307805 @default.
• W4319773032 cites W2088969512 @default.
• W4319773032 cites W2090260381 @default.
• W4319773032 cites W2098272219 @default.
• W4319773032 cites W2102619694 @default.
• W4319773032 cites W2103619902 @default.
• W4319773032 cites W2105241566 @default.
• W4319773032 cites W2107575419 @default.
• W4319773032 cites W2108241558 @default.
• W4319773032 cites W2108451330 @default.
• W4319773032 cites W2118089461 @default.
• W4319773032 cites W2120076861 @default.
• W4319773032 cites W2123355890 @default.
• W4319773032 cites W2124432567 @default.
• W4319773032 cites W2124985265 @default.
• W4319773032 cites W2125987139 @default.
• W4319773032 cites W2127650961 @default.
• W4319773032 cites W2137644219 @default.
• W4319773032 cites W2142046859 @default.
• W4319773032 cites W2142482111 @default.
• W4319773032 cites W2142806844 @default.
• W4319773032 cites W2148272837 @default.
• W4319773032 cites W2151220183 @default.
• W4319773032 cites W2151870437 @default.
• W4319773032 cites W2152194113 @default.
• W4319773032 cites W2152426454 @default.
• W4319773032 cites W2155018872 @default.
• W4319773032 cites W2158749497 @default.
• W4319773032 cites W2169187183 @default.
• W4319773032 cites W2169456326 @default.
• W4319773032 cites W2170830174 @default.
• W4319773032 cites W2171808845 @default.
• W4319773032 cites W2175853567 @default.
• W4319773032 cites W2179438025 @default.
• W4319773032 cites W2273958019 @default.
• W4319773032 cites W2274491524 @default.

• next