Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319782909> ?p ?o ?g. }
- W4319782909 endingPage "106477" @default.
- W4319782909 startingPage "106477" @default.
- W4319782909 abstract "Animal studies indicate that a high-fat/high-sugar diet (HFS) can change dopamine signal transmission in the brain, which could promote maladaptive behavior and decision-making. Such diet-induced changes may also explain observed alterations in the dopamine system in human obesity. Genetic variants that modulate dopamine transmission have been proposed to render some individuals more prone to potential effects of HFS. The objective of this study was to investigate the association of HFS with dopamine-dependent cognition in humans and how genetic variations might modulate this potential association. Using a questionnaire assessing the self-reported consumption of high-fat/high-sugar foods, we investigated the association with diet by recruiting healthy young men that fall into the lower or upper end of that questionnaire (low fat/sugar group: LFS, n = 45; high fat/sugar group: HFS, n = 41) and explored the interaction of fat and sugar consumption with COMT Val158Met and Taq1A genotype. During functional magnetic resonance imaging (fMRI) scanning, male participants performed a working memory (WM) task that probes distractor-resistance and updating of WM representations. Logistic and linear regression models revealed no significant difference in WM performance between the two diet groups, nor an interaction with COMT Val158Met or Taq1A genotype. Neural activation in task-related brain areas also did not differ between diet groups. Independent of diet group, higher BMI was associated with lower overall accuracy on the WM task. This cross-sectional study does not provide evidence for diet-related differences in WM stability and flexibility in men, nor for a predisposition of COMT Val158Met or Taq1A genotype to the hypothesized detrimental effects of an HFS diet. Previously reported associations of BMI with WM seem to be independent of HFS intake in our male study sample." @default.
- W4319782909 created "2023-02-11" @default.
- W4319782909 creator A5020852049 @default.
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- W4319782909 creator A5037661696 @default.
- W4319782909 creator A5072290857 @default.
- W4319782909 creator A5076451044 @default.
- W4319782909 date "2023-04-01" @default.
- W4319782909 modified "2023-09-26" @default.
- W4319782909 title "Self-reported intake of high-fat and high-sugar diet is not associated with cognitive stability and flexibility in healthy men" @default.
- W4319782909 cites W1555802611 @default.
- W4319782909 cites W1606961096 @default.
- W4319782909 cites W1608425508 @default.
- W4319782909 cites W1659384861 @default.
- W4319782909 cites W1963548052 @default.
- W4319782909 cites W1964979617 @default.
- W4319782909 cites W1966148872 @default.
- W4319782909 cites W1971374576 @default.
- W4319782909 cites W1971966003 @default.
- W4319782909 cites W1972441556 @default.
- W4319782909 cites W1973197910 @default.
- W4319782909 cites W1975134899 @default.
- W4319782909 cites W1980932677 @default.
- W4319782909 cites W1991526895 @default.
- W4319782909 cites W1993177597 @default.
- W4319782909 cites W1994124622 @default.
- W4319782909 cites W1994687974 @default.
- W4319782909 cites W1999351864 @default.
- W4319782909 cites W2003413351 @default.
- W4319782909 cites W2005238835 @default.
- W4319782909 cites W2005336684 @default.
- W4319782909 cites W2011790043 @default.
- W4319782909 cites W2012499198 @default.
- W4319782909 cites W2022961682 @default.
- W4319782909 cites W2038491209 @default.
- W4319782909 cites W2039148287 @default.
- W4319782909 cites W2040517865 @default.
- W4319782909 cites W2048055615 @default.
- W4319782909 cites W2049763569 @default.
- W4319782909 cites W2054856852 @default.
- W4319782909 cites W2056671172 @default.
- W4319782909 cites W2057199800 @default.
- W4319782909 cites W2069923399 @default.
- W4319782909 cites W2070417850 @default.
- W4319782909 cites W2079040703 @default.
- W4319782909 cites W2080154833 @default.
- W4319782909 cites W2083980029 @default.
- W4319782909 cites W2086242497 @default.
- W4319782909 cites W2094134651 @default.
- W4319782909 cites W2094222502 @default.
- W4319782909 cites W2094707772 @default.
- W4319782909 cites W2096847430 @default.
- W4319782909 cites W2100040984 @default.
- W4319782909 cites W2102348676 @default.
- W4319782909 cites W2102548837 @default.
- W4319782909 cites W2103685082 @default.
- W4319782909 cites W2103806952 @default.
- W4319782909 cites W2106185461 @default.
- W4319782909 cites W2107413278 @default.
- W4319782909 cites W2108434913 @default.
- W4319782909 cites W2115081828 @default.
- W4319782909 cites W2118667631 @default.
- W4319782909 cites W2119314959 @default.
- W4319782909 cites W2123072302 @default.
- W4319782909 cites W2130978024 @default.
- W4319782909 cites W2131355275 @default.
- W4319782909 cites W2135987364 @default.
- W4319782909 cites W2137232739 @default.
- W4319782909 cites W2139412441 @default.
- W4319782909 cites W2139913331 @default.
- W4319782909 cites W2141549131 @default.
- W4319782909 cites W2141687868 @default.
- W4319782909 cites W2142709570 @default.
- W4319782909 cites W2146220657 @default.
- W4319782909 cites W2148487173 @default.
- W4319782909 cites W2150769483 @default.
- W4319782909 cites W2160234571 @default.
- W4319782909 cites W2171129594 @default.
- W4319782909 cites W2205349065 @default.
- W4319782909 cites W2301701533 @default.
- W4319782909 cites W2324696545 @default.
- W4319782909 cites W2414283218 @default.
- W4319782909 cites W2536051580 @default.
- W4319782909 cites W2566590101 @default.
- W4319782909 cites W2567318264 @default.
- W4319782909 cites W2567447937 @default.
- W4319782909 cites W2587375768 @default.
- W4319782909 cites W2591566720 @default.
- W4319782909 cites W2598506183 @default.
- W4319782909 cites W2599551061 @default.
- W4319782909 cites W2602661268 @default.
- W4319782909 cites W2607366508 @default.
- W4319782909 cites W2626149533 @default.
- W4319782909 cites W2749359340 @default.
- W4319782909 cites W2762751960 @default.
- W4319782909 cites W2773089253 @default.