Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319786711> ?p ?o ?g. }
- W4319786711 endingPage "110506" @default.
- W4319786711 startingPage "110506" @default.
- W4319786711 abstract "In this study, the ability of the phosphatidylcholine (PC) molecule, which is in the tear films in human eyes, to release the fluorometholone (FLU) drug from the sulfobutylether-β-cyclodextrin (SBE-β-CD) carrier, is investigated. The binding energy obtained from the density functional theory (DFT) calculations shows that the PC molecule affinity to bind with the SBE-β-CD is higher than that of the FLU molecule. In addition, the results of molecular dynamic (MD) simulations revealed that PC could interact with the carrier through both coulombic and L-J interactions (Ecoul = ∼−206 and EL-J = ∼−190 kJ/mol), while FLU interaction with SBE-β-CD is mainly via van der Waals interactions (Ecoul = ∼−49 and EL-J = ∼−125 kJ/mol). The obtained results show that in both studied systems, H-bond formation is the driving force in stabilizing these structures. The results confirmed that the Phosphatidylcholine could replace the fluorometholone in the carrier cavity and release the drug in the target site. Overall, our findings demonstrate that SBE-β-CD&FLU complex can be a suitable alternative for treating inflammatory disorders of the eye over the conventional delivery systems." @default.
- W4319786711 created "2023-02-11" @default.
- W4319786711 creator A5026747204 @default.
- W4319786711 creator A5055204846 @default.
- W4319786711 creator A5060111043 @default.
- W4319786711 creator A5075596716 @default.
- W4319786711 date "2023-04-01" @default.
- W4319786711 modified "2023-10-02" @default.
- W4319786711 title "Phosphatidylcholine in the tear film of the eye: Enhanced topical delivery of fluorometholone to the eye" @default.
- W4319786711 cites W1031578623 @default.
- W4319786711 cites W177460480 @default.
- W4319786711 cites W1802895804 @default.
- W4319786711 cites W1918323027 @default.
- W4319786711 cites W1976499671 @default.
- W4319786711 cites W1978285976 @default.
- W4319786711 cites W2029667189 @default.
- W4319786711 cites W2032032786 @default.
- W4319786711 cites W2035266068 @default.
- W4319786711 cites W2041791898 @default.
- W4319786711 cites W2057477511 @default.
- W4319786711 cites W2058181522 @default.
- W4319786711 cites W2066510699 @default.
- W4319786711 cites W2073516253 @default.
- W4319786711 cites W2074582913 @default.
- W4319786711 cites W2095474273 @default.
- W4319786711 cites W2104919283 @default.
- W4319786711 cites W2112327432 @default.
- W4319786711 cites W2132262459 @default.
- W4319786711 cites W2132525235 @default.
- W4319786711 cites W2150697053 @default.
- W4319786711 cites W2156932023 @default.
- W4319786711 cites W2162049727 @default.
- W4319786711 cites W2162884629 @default.
- W4319786711 cites W2164827516 @default.
- W4319786711 cites W2171445884 @default.
- W4319786711 cites W2585894021 @default.
- W4319786711 cites W2754708563 @default.
- W4319786711 cites W2887843846 @default.
- W4319786711 cites W2898126612 @default.
- W4319786711 cites W2899893952 @default.
- W4319786711 cites W2902112338 @default.
- W4319786711 cites W2939878646 @default.
- W4319786711 cites W2944971391 @default.
- W4319786711 cites W2945069273 @default.
- W4319786711 cites W2969222811 @default.
- W4319786711 cites W2980679456 @default.
- W4319786711 cites W2995994533 @default.
- W4319786711 cites W3102264809 @default.
- W4319786711 cites W3102397932 @default.
- W4319786711 cites W3105180795 @default.
- W4319786711 cites W3153294808 @default.
- W4319786711 cites W3156020994 @default.
- W4319786711 cites W3163327463 @default.
- W4319786711 cites W3172845682 @default.
- W4319786711 cites W3196867349 @default.
- W4319786711 cites W3209496489 @default.
- W4319786711 cites W4200223773 @default.
- W4319786711 cites W4206017762 @default.
- W4319786711 cites W4283758689 @default.
- W4319786711 cites W982559743 @default.
- W4319786711 doi "https://doi.org/10.1016/j.inoche.2023.110506" @default.
- W4319786711 hasPublicationYear "2023" @default.
- W4319786711 type Work @default.
- W4319786711 citedByCount "2" @default.
- W4319786711 countsByYear W43197867112023 @default.
- W4319786711 crossrefType "journal-article" @default.
- W4319786711 hasAuthorship W4319786711A5026747204 @default.
- W4319786711 hasAuthorship W4319786711A5055204846 @default.
- W4319786711 hasAuthorship W4319786711A5060111043 @default.
- W4319786711 hasAuthorship W4319786711A5075596716 @default.
- W4319786711 hasConcept C126061179 @default.
- W4319786711 hasConcept C147597530 @default.
- W4319786711 hasConcept C152365726 @default.
- W4319786711 hasConcept C178790620 @default.
- W4319786711 hasConcept C185592680 @default.
- W4319786711 hasConcept C2776330855 @default.
- W4319786711 hasConcept C2778918659 @default.
- W4319786711 hasConcept C2779820397 @default.
- W4319786711 hasConcept C32909587 @default.
- W4319786711 hasConcept C41625074 @default.
- W4319786711 hasConcept C55493867 @default.
- W4319786711 hasConcept C71240020 @default.
- W4319786711 hasConceptScore W4319786711C126061179 @default.
- W4319786711 hasConceptScore W4319786711C147597530 @default.
- W4319786711 hasConceptScore W4319786711C152365726 @default.
- W4319786711 hasConceptScore W4319786711C178790620 @default.
- W4319786711 hasConceptScore W4319786711C185592680 @default.
- W4319786711 hasConceptScore W4319786711C2776330855 @default.
- W4319786711 hasConceptScore W4319786711C2778918659 @default.
- W4319786711 hasConceptScore W4319786711C2779820397 @default.
- W4319786711 hasConceptScore W4319786711C32909587 @default.
- W4319786711 hasConceptScore W4319786711C41625074 @default.
- W4319786711 hasConceptScore W4319786711C55493867 @default.
- W4319786711 hasConceptScore W4319786711C71240020 @default.
- W4319786711 hasLocation W43197867111 @default.
- W4319786711 hasOpenAccess W4319786711 @default.
- W4319786711 hasPrimaryLocation W43197867111 @default.
- W4319786711 hasRelatedWork W133704394 @default.