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- W4319787060 abstract "To assess retinal and choroidal thickness changes in chronic kidney disease (CKD) patients using spectral domain optical coherence tomography (SD-OCT).CKD is a devastating health trouble. The eye and the kidney share similar structural and genetic pathways, so that kidney disease and ocular disease may be closely linked. OCT is a precise, fast method for high-definition scanning of the retina and choroid.A cross sectional study was conducted at Menoufia University Hospital ophthalmology department on 144 eyes of 72 CKD patients divided into 3 groups according to the stage of CKD as follows: group 1: CKD stage 1-2, with Glomerular Filtration Rate (GFR) > 60 ml/min/1.73m2 group 2: CKD stage 3, GFR 30-59 ml/min/1.73m2 and group 3: CKD stage 4-5, eGFR < 29 ml/min/1.73m2. All patients underwent full ophthalmologic examination followed by OCT assessment of retinal, retinal nerve fiber layer (RNFL) and choroidal thickness.Retinal and choroidal thickness were reduced in group 2 (CKD stage 3) and group 3 (CKD stage 4-5) compared with group 1 (CKD stage 1-2). The reduction was more severe in group 3 than group 2. RNFL thickness did not differ between groups. A thinner retina and choroid were associated with an elevated serum C-reactive protein (CRP) concentration, and greater degrees of proteinuria.Chorioretinal thinning in CKD is associated with a lower eGFR, a higher CRP, and greater proteinuria. Further studies, in a large scale of patients, are needed to detect whether these eye changes reflect the natural history of CKD." @default.
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- W4319787060 date "2023-02-09" @default.
- W4319787060 modified "2023-09-26" @default.
- W4319787060 title "Association of chorioretinal thickness with chronic kidney disease" @default.
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- W4319787060 doi "https://doi.org/10.1186/s12886-023-02802-x" @default.
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