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- W4319788402 abstract "Background/Aim Depression has become a multiple disease worldwide, and is closely related to the systemic inflammatory response. Methods Based on the data of the National Health and Nutrition Examination Survey (NHANES), this study included 2,514 depressive and 26,487 non-depressive adults. The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) were used to quantify systemic inflammation. The multivariate logistic regression and inverse probability weighting methods were used to analyze the effect size of SII and SIRI on the risk of depression. Results After adjusting for all confounders, the above associations of SII and SIRI with depression risk remained significant (SII, OR = 1.02, 95% CI = 1.01 to 1.02, p = 0.001; SIRI, OR = 1.06, 95% CI = 1.01 to 1.10, p = 0.016). Each 100-unit increase in SII was associated with a 2% increase in the risk of depression, while each one-unit increase in SIRI was associated with a 6% increase in the risk of depression. Conclusion Systemic inflammatory biomarkers (SII and SIRI) significantly affected the risk of depression. SII or SIRI can serve as a biomarker of anti-inflammation treatment for depression." @default.
- W4319788402 created "2023-02-11" @default.
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- W4319788402 date "2023-02-08" @default.
- W4319788402 modified "2023-10-16" @default.
- W4319788402 title "Association of systemic inflammatory biomarkers with depression risk: Results from National Health and Nutrition Examination Survey 2005–2018 analyses" @default.
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- W4319788402 doi "https://doi.org/10.3389/fpsyt.2023.1097196" @default.
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