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- W4319789837 abstract "Abstract This study establishes the first organocatalytic enantioselective synthesis of axially chiral N , N′ ‐bisindoles via chiral phosphoric acid‐catalyzed formal (3+2) cycloadditions of indole‐based enaminones as novel platform molecules with 2,3‐diketoesters, where de novo indole‐ring formation is involved. Using this new strategy, various axially chiral N , N′ ‐bisindoles were synthesized in good yields and with excellent enantioselectivities (up to 87 % yield and 96 % ee). More importantly, this class of axially chiral N , N′ ‐bisindoles exhibited some degree of cytotoxicity toward cancer cells and was derived into axially chiral phosphine ligands with high catalytic activity. This study provides a new strategy for enantioselective synthesis of axially chiral N , N′ ‐bisindoles using asymmetric organocatalysis and is the first to realize the applications of such scaffolds in medicinal chemistry and asymmetric catalysis." @default.
- W4319789837 created "2023-02-11" @default.
- W4319789837 creator A5007707257 @default.
- W4319789837 creator A5032970337 @default.
- W4319789837 creator A5059742747 @default.
- W4319789837 creator A5066097652 @default.
- W4319789837 creator A5080185675 @default.
- W4319789837 creator A5083249296 @default.
- W4319789837 creator A5086163138 @default.
- W4319789837 date "2023-02-21" @default.
- W4319789837 modified "2023-10-14" @default.
- W4319789837 title "Organocatalytic Enantioselective Synthesis of Axially Chiral <i>N</i>,<i>N′</i>‐Bisindoles" @default.
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