Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319813058> ?p ?o ?g. }
- W4319813058 endingPage "801" @default.
- W4319813058 startingPage "790" @default.
- W4319813058 abstract "The extracellular matrix (ECM) is a critical non-cellular component of multicellular organisms containing a variety of proteins, glycoproteins, and proteoglycans which have been implicated in a wide variety of essential biological processes, including development, wound healing, and aging. Due to low solubility, many ECM proteins have been underrepresented in previous proteomic datasets. Using an optimized three-step decellularization and ECM extraction method involving chaotrope extraction and digestion via hydroxylamine hydrochloride, we have generated coverage of the matrisome across 25 organs. We observe that the top 100 most abundant proteins from the ECM fractions of all tissues are generally present in all tissues, indicating that tissue matrices are principally composed of a shared set of ECM proteins. However, these proteins vary up to 4000-fold between tissues, resulting in highly unique matrix profiles even with the same primary set of proteins. A data reduction approach was used to reveal related networks of expressed ECM proteins across varying tissues, including basement membrane and collagen subtypes." @default.
- W4319813058 created "2023-02-11" @default.
- W4319813058 creator A5002543820 @default.
- W4319813058 creator A5076307322 @default.
- W4319813058 creator A5077150143 @default.
- W4319813058 date "2023-02-10" @default.
- W4319813058 modified "2023-10-10" @default.
- W4319813058 title "Mass Spectrometry-Based Atlas of Extracellular Matrix Proteins across 25 Mouse Organs" @default.
- W4319813058 cites W1841404445 @default.
- W4319813058 cites W1879220818 @default.
- W4319813058 cites W1965157206 @default.
- W4319813058 cites W1965498876 @default.
- W4319813058 cites W1980325398 @default.
- W4319813058 cites W1992444004 @default.
- W4319813058 cites W1997583644 @default.
- W4319813058 cites W2001379151 @default.
- W4319813058 cites W2005532985 @default.
- W4319813058 cites W2012034410 @default.
- W4319813058 cites W2013001348 @default.
- W4319813058 cites W2034156947 @default.
- W4319813058 cites W2037199116 @default.
- W4319813058 cites W2038588642 @default.
- W4319813058 cites W2045295282 @default.
- W4319813058 cites W2051349181 @default.
- W4319813058 cites W2055624921 @default.
- W4319813058 cites W2064297038 @default.
- W4319813058 cites W2080752012 @default.
- W4319813058 cites W2091656580 @default.
- W4319813058 cites W2096164500 @default.
- W4319813058 cites W2096539671 @default.
- W4319813058 cites W2104947426 @default.
- W4319813058 cites W2135428072 @default.
- W4319813058 cites W2145080262 @default.
- W4319813058 cites W2149313980 @default.
- W4319813058 cites W2151136501 @default.
- W4319813058 cites W2161000333 @default.
- W4319813058 cites W2162716266 @default.
- W4319813058 cites W2167844024 @default.
- W4319813058 cites W2169848124 @default.
- W4319813058 cites W2183417521 @default.
- W4319813058 cites W2331628193 @default.
- W4319813058 cites W2337683177 @default.
- W4319813058 cites W2441337908 @default.
- W4319813058 cites W2474510574 @default.
- W4319813058 cites W2510899048 @default.
- W4319813058 cites W2515557525 @default.
- W4319813058 cites W2556725207 @default.
- W4319813058 cites W2566791050 @default.
- W4319813058 cites W2567747263 @default.
- W4319813058 cites W2623649881 @default.
- W4319813058 cites W2624992840 @default.
- W4319813058 cites W2691615730 @default.
- W4319813058 cites W2763329657 @default.
- W4319813058 cites W2766638900 @default.
- W4319813058 cites W2801307395 @default.
- W4319813058 cites W2890360767 @default.
- W4319813058 cites W2914365350 @default.
- W4319813058 cites W2918715331 @default.
- W4319813058 cites W2941499827 @default.
- W4319813058 cites W2971483070 @default.
- W4319813058 cites W2972443643 @default.
- W4319813058 cites W2978880851 @default.
- W4319813058 cites W2993894543 @default.
- W4319813058 cites W2998666372 @default.
- W4319813058 cites W3036810437 @default.
- W4319813058 cites W3081276404 @default.
- W4319813058 cites W3091579399 @default.
- W4319813058 cites W3127097062 @default.
- W4319813058 cites W3134747323 @default.
- W4319813058 cites W3154361210 @default.
- W4319813058 cites W3205012216 @default.
- W4319813058 cites W3206070317 @default.
- W4319813058 cites W3207648832 @default.
- W4319813058 cites W4212903566 @default.
- W4319813058 cites W4233255713 @default.
- W4319813058 cites W4281866421 @default.
- W4319813058 cites W4282958823 @default.
- W4319813058 cites W4283034207 @default.
- W4319813058 doi "https://doi.org/10.1021/acs.jproteome.2c00526" @default.
- W4319813058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36763087" @default.
- W4319813058 hasPublicationYear "2023" @default.
- W4319813058 type Work @default.
- W4319813058 citedByCount "9" @default.
- W4319813058 countsByYear W43198130582022 @default.
- W4319813058 countsByYear W43198130582023 @default.
- W4319813058 crossrefType "journal-article" @default.
- W4319813058 hasAuthorship W4319813058A5002543820 @default.
- W4319813058 hasAuthorship W4319813058A5076307322 @default.
- W4319813058 hasAuthorship W4319813058A5077150143 @default.
- W4319813058 hasBestOaLocation W43198130582 @default.
- W4319813058 hasConcept C104317684 @default.
- W4319813058 hasConcept C108625454 @default.
- W4319813058 hasConcept C131075544 @default.
- W4319813058 hasConcept C144647389 @default.
- W4319813058 hasConcept C160160445 @default.
- W4319813058 hasConcept C181199279 @default.
- W4319813058 hasConcept C185592680 @default.
- W4319813058 hasConcept C189165786 @default.