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- W4319827346 abstract "Background: Among the important key modulators of the tumor microenvironment and hypoxia is a family of enzymes named carbonic anhydrases. Herein, 11 novel sulfonamide–pyridine hybrids (2–12) were designed, synthesized and biologically evaluated for their potential use in targeting breast cancer. Methods & results: The para chloro derivative 7 reported the highest cytotoxic activity against the three breast cancer cell lines used. In addition, compound 7 was found to induce cell cycle arrest and autophagy as well as delaying wound healing. The IC 50 of compound 7 against carbonic anhydrase IX was 253 ± 12 nM using dorzolamide HCl as control. Conclusion: This study encourages us to expand the designed library, where more sulfonamide derivatives would be synthesized and studied for their structure–activity relationships." @default.
- W4319827346 created "2023-02-11" @default.
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- W4319827346 creator A5055118173 @default.
- W4319827346 creator A5072172025 @default.
- W4319827346 date "2023-02-10" @default.
- W4319827346 modified "2023-09-27" @default.
- W4319827346 title "Challenging breast cancer through novel sulfonamide–pyridine hybrids: design, synthesis, carbonic anhydrase IX inhibition and induction of apoptosis" @default.
- W4319827346 cites W1514420217 @default.
- W4319827346 cites W1535297401 @default.
- W4319827346 cites W1600178338 @default.
- W4319827346 cites W1602845909 @default.
- W4319827346 cites W1713680667 @default.
- W4319827346 cites W1733601379 @default.
- W4319827346 cites W1971905772 @default.
- W4319827346 cites W1988650737 @default.
- W4319827346 cites W1989722723 @default.
- W4319827346 cites W2000584792 @default.
- W4319827346 cites W2023254001 @default.
- W4319827346 cites W2030612441 @default.
- W4319827346 cites W2034233153 @default.
- W4319827346 cites W2039366858 @default.
- W4319827346 cites W2046124687 @default.
- W4319827346 cites W2048177691 @default.
- W4319827346 cites W2053257221 @default.
- W4319827346 cites W2053750421 @default.
- W4319827346 cites W2055738624 @default.
- W4319827346 cites W2058453319 @default.
- W4319827346 cites W2069849503 @default.
- W4319827346 cites W2071579644 @default.
- W4319827346 cites W2098275471 @default.
- W4319827346 cites W2101908524 @default.
- W4319827346 cites W2105668062 @default.
- W4319827346 cites W2106030067 @default.
- W4319827346 cites W2107136437 @default.
- W4319827346 cites W2109689528 @default.
- W4319827346 cites W2114129118 @default.
- W4319827346 cites W2117692326 @default.
- W4319827346 cites W2119752391 @default.
- W4319827346 cites W2130479394 @default.
- W4319827346 cites W2132629607 @default.
- W4319827346 cites W2133679043 @default.
- W4319827346 cites W2144715185 @default.
- W4319827346 cites W2158838439 @default.
- W4319827346 cites W2164460325 @default.
- W4319827346 cites W2165526004 @default.
- W4319827346 cites W2169678694 @default.
- W4319827346 cites W2273836722 @default.
- W4319827346 cites W2513003657 @default.
- W4319827346 cites W2531127385 @default.
- W4319827346 cites W2540663276 @default.
- W4319827346 cites W2558044116 @default.
- W4319827346 cites W2596629479 @default.
- W4319827346 cites W2616790281 @default.
- W4319827346 cites W2740059367 @default.
- W4319827346 cites W2760919908 @default.
- W4319827346 cites W2781664750 @default.
- W4319827346 cites W2782469510 @default.
- W4319827346 cites W2783760997 @default.
- W4319827346 cites W2803144214 @default.
- W4319827346 cites W2804403849 @default.
- W4319827346 cites W2807094378 @default.
- W4319827346 cites W2808223966 @default.
- W4319827346 cites W2808592409 @default.
- W4319827346 cites W2883364911 @default.
- W4319827346 cites W2891625480 @default.
- W4319827346 cites W2896603322 @default.
- W4319827346 cites W2901194941 @default.
- W4319827346 cites W2901679478 @default.
- W4319827346 cites W2944503022 @default.
- W4319827346 cites W2954297401 @default.
- W4319827346 cites W2990330375 @default.
- W4319827346 cites W2995808420 @default.
- W4319827346 cites W3000411337 @default.
- W4319827346 cites W3009541903 @default.
- W4319827346 cites W3014500359 @default.
- W4319827346 cites W3026463183 @default.
- W4319827346 cites W3028161460 @default.
- W4319827346 cites W3043351172 @default.
- W4319827346 cites W3047040017 @default.
- W4319827346 cites W3068772833 @default.
- W4319827346 cites W3093450407 @default.
- W4319827346 cites W3121420611 @default.
- W4319827346 cites W3128646645 @default.
- W4319827346 cites W3130949183 @default.
- W4319827346 cites W3139507450 @default.
- W4319827346 cites W3166002589 @default.
- W4319827346 cites W3169802945 @default.
- W4319827346 cites W3183264666 @default.
- W4319827346 cites W3203808271 @default.
- W4319827346 cites W4200278775 @default.
- W4319827346 cites W4206258397 @default.
- W4319827346 cites W4220932743 @default.
- W4319827346 doi "https://doi.org/10.4155/fmc-2022-0197" @default.
- W4319827346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36762576" @default.
- W4319827346 hasPublicationYear "2023" @default.
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