Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319870789> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4319870789 endingPage "209a" @default.
- W4319870789 startingPage "209a" @default.
- W4319870789 abstract "Recent evidence demonstrates that large centrosomal coiled-coil (CC) proteins—such as pericentrin, centrosomin, and spd-5—undergo biological liquid-liquid phase separation (PS) in the cell. These large CC proteins contain several CC domains and stretches of disordered regions in between. CC domains are well known for their ability to complex with each other and form a variety of oligomers. Given that CC domains are common in centrosome-related proteins that show PS, and recognizing that the associative nature of CC domains suggests they could contribute multivalent interactions, we are led to ask: Are CC domains themselves sufficient to drive PS of proteins? The link between CC domains and multivalency has not yet been demonstrated largely because the CC proteins that phase separate—which are not explained by other phase-separating mechanisms—are large, disordered, and intractable to work with in vitro. We address this question with molecular simulation using a customizable coarse-grained model of CC proteins. By changing the number of coils, the oligomeric state of the coils, and the interaction specificity between coils, we can obtain a wide variety of behavior ranging from full liquid-liquid PS to distributions of higher order clusters." @default.
- W4319870789 created "2023-02-11" @default.
- W4319870789 creator A5028214935 @default.
- W4319870789 creator A5080360440 @default.
- W4319870789 creator A5080566697 @default.
- W4319870789 date "2023-02-01" @default.
- W4319870789 modified "2023-10-14" @default.
- W4319870789 title "Coiled-coil domains can drive liquid-liquid phase separation" @default.
- W4319870789 doi "https://doi.org/10.1016/j.bpj.2022.11.1254" @default.
- W4319870789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36783012" @default.
- W4319870789 hasPublicationYear "2023" @default.
- W4319870789 type Work @default.
- W4319870789 citedByCount "2" @default.
- W4319870789 countsByYear W43198707892022 @default.
- W4319870789 crossrefType "journal-article" @default.
- W4319870789 hasAuthorship W4319870789A5028214935 @default.
- W4319870789 hasAuthorship W4319870789A5080360440 @default.
- W4319870789 hasAuthorship W4319870789A5080566697 @default.
- W4319870789 hasConcept C10447061 @default.
- W4319870789 hasConcept C12554922 @default.
- W4319870789 hasConcept C1491633281 @default.
- W4319870789 hasConcept C159467904 @default.
- W4319870789 hasConcept C178790620 @default.
- W4319870789 hasConcept C185592680 @default.
- W4319870789 hasConcept C186060115 @default.
- W4319870789 hasConcept C29537977 @default.
- W4319870789 hasConcept C3017397382 @default.
- W4319870789 hasConcept C43617362 @default.
- W4319870789 hasConcept C44280652 @default.
- W4319870789 hasConcept C55493867 @default.
- W4319870789 hasConcept C55988834 @default.
- W4319870789 hasConcept C86803240 @default.
- W4319870789 hasConceptScore W4319870789C10447061 @default.
- W4319870789 hasConceptScore W4319870789C12554922 @default.
- W4319870789 hasConceptScore W4319870789C1491633281 @default.
- W4319870789 hasConceptScore W4319870789C159467904 @default.
- W4319870789 hasConceptScore W4319870789C178790620 @default.
- W4319870789 hasConceptScore W4319870789C185592680 @default.
- W4319870789 hasConceptScore W4319870789C186060115 @default.
- W4319870789 hasConceptScore W4319870789C29537977 @default.
- W4319870789 hasConceptScore W4319870789C3017397382 @default.
- W4319870789 hasConceptScore W4319870789C43617362 @default.
- W4319870789 hasConceptScore W4319870789C44280652 @default.
- W4319870789 hasConceptScore W4319870789C55493867 @default.
- W4319870789 hasConceptScore W4319870789C55988834 @default.
- W4319870789 hasConceptScore W4319870789C86803240 @default.
- W4319870789 hasIssue "3" @default.
- W4319870789 hasLocation W43198707891 @default.
- W4319870789 hasLocation W43198707892 @default.
- W4319870789 hasOpenAccess W4319870789 @default.
- W4319870789 hasPrimaryLocation W43198707891 @default.
- W4319870789 hasRelatedWork W1976781391 @default.
- W4319870789 hasRelatedWork W2021002630 @default.
- W4319870789 hasRelatedWork W2025351437 @default.
- W4319870789 hasRelatedWork W2145489844 @default.
- W4319870789 hasRelatedWork W2337145605 @default.
- W4319870789 hasRelatedWork W2584548500 @default.
- W4319870789 hasRelatedWork W2780519320 @default.
- W4319870789 hasRelatedWork W4377018860 @default.
- W4319870789 hasRelatedWork W4379261013 @default.
- W4319870789 hasRelatedWork W2554543517 @default.
- W4319870789 hasVolume "122" @default.
- W4319870789 isParatext "false" @default.
- W4319870789 isRetracted "false" @default.
- W4319870789 workType "article" @default.