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- W4319874884 abstract "This chapter deals with inhibitors that bind slowly to the enzyme on the time scale of enzymatic turnover and thus displays a change in initial velocity with time. These inhibitors act as slow-binding or time-dependent inhibitors of the enzyme. An alternative enzyme isomerization mechanism can be envisaged in which the free enzyme slowly isomerizes between two alternative conformational states, only one of which is capable of binding inhibitor. Over a period in which the uninhibited enzyme displays a simple linear progress curve, the data in the presence of the slow-binding inhibitor will display a quasi-linear relationship with time in the early part of the curve, converting later to a different linear relationship between product and time. Morrison states that almost all slow-binding enzyme inhibitors act as competitive inhibitors, binding at the enzyme active site." @default.
- W4319874884 created "2023-02-11" @default.
- W4319874884 date "2023-02-10" @default.
- W4319874884 modified "2023-10-12" @default.
- W4319874884 title "TIME‐DEPENDENT INHIBITION" @default.
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- W4319874884 doi "https://doi.org/10.1002/9781119793304.ch12" @default.
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