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• W4319874930 endingPage "541" @default.
• W4319874930 startingPage "487" @default.
• W4319874930 abstract "A number of familial diseases are associated with diminished concentration or loss of function of key enzymes, and therapeutic approaches, based on enzyme replacement, have been successful in treating some of these inborn errors in metabolism. Administration of tissue plasminogen activator (tPA) has also been used to treat frostbite, based on the potential of tPA to lyse microvascular thrombi; tPA treatment of frostbite patients has been reported to result in a reduced incidence of subsequent amputations. In addition to diseases associated with diminished enzymatic function, there are a large number of human diseases that rely on the normal or altered activity of specific enzymes. The effectiveness of an enzyme inhibitor in combating disease depends on its potency for the intended target and the veracity of the underlying hypothesis that the disease is critically dependent on the activity of the target enzyme." @default.
• W4319874930 created "2023-02-11" @default.
• W4319874930 date "2023-02-10" @default.
• W4319874930 modified "2023-10-12" @default.
• W4319874930 title "ENZYMES IN HUMAN HEALTH" @default.
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• W4319874930 doi "https://doi.org/10.1002/9781119793304.ch17" @default.

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