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- W4319880060 abstract "Antibiotic resistance is a growing worldwide human health issue that is now threatening to render us vulnerable once again to infections that have been treatable for decades. Various approaches have been proposed in the effort to overcome this threat and effectively treat bacterial infections. We report the use of DNA origami nanostructures [1], functionalized with aptamers, as a vehicle for delivering the antimicrobials in a specific and efficient manner. We test the system against Gram positive (Bacillus subtilis) and Gram negative (Escherichia coli) targets. We use direct stochastic optical reconstruction microscopy (dSTORM) and atomic force microscopy (AFM) to characterize the DNA origami nanostructures and structured illumination microscopy (SIM) to assess the binding of the origami to the bacteria. We show that treatment with lysozyme-functionalized origami slows bacterial growth more effectively than treatment with free lysozyme. Our study introduces DNA origami as a tool in the fight against antibiotic resistance, and our results demonstrate the specificity and efficiency of the nanostructure as a drug delivery vehicle. [1] I. Mela, P. P. Vallejo-Ramirez, S. Makarchuk, G. Christie, D. Bailey, R. M. Henderson, H. Sugiyama, M. Endo, C. F. Kaminski, Angew. Chem. Int. Ed. 2020, 59, 12698, https://doi.org/10.1002/anie.202002740." @default.
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- W4319880060 date "2023-02-01" @default.
- W4319880060 modified "2023-09-25" @default.
- W4319880060 title "DNA nanostructures as a tool for targeted antimicrobial delivery" @default.
- W4319880060 doi "https://doi.org/10.1016/j.bpj.2022.11.2910" @default.
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