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- W4319880301 abstract "Morphological changes and the mechanical response of cells are potent biomarkers for a variety of diseases. Quantitative understanding of these morphological (volume or surface area) and mechanical (stiffness) changes in cells caused by different pathogens, or chemicals/drugs can be vital for disease diagnosis and large-scale population screening in low-resource conditions. We present a high-throughput electro-fluidic device with single cell resolution to detect these biophysical changes in cells. The system works on modified resistive pulse technique, where the parameters dwell time and change in conductance are mapped to cell stiffness and cell size, respectively. We demonstrate applications of our device in detecting cell's mechanical changes caused by chemical exposure (drug exposure or change in tonicity), pathogen infection (e.g., malaria), and genetic changes (e.g., sickle-cell anemia). Our electro-fluidic system is portable, low cost and easy to build. The system is currently optimized for stiffness measurements of Red Blood Cells, and is ready for point-of-care applications in hospitals or rural areas for hematological screening." @default.
- W4319880301 created "2023-02-11" @default.
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- W4319880301 date "2023-02-01" @default.
- W4319880301 modified "2023-09-30" @default.
- W4319880301 title "Measurement of cellular stiffness for diagnostic applications" @default.
- W4319880301 doi "https://doi.org/10.1016/j.bpj.2022.11.2815" @default.
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