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- W4319880425 abstract "Certain biological nanopores have been shown to have stochastic sensing properties, allowing detection of translocating molecules by application of a voltage to the nanopore and measurement of the resulting current output. This methodology necessitates that interacting molecules produce current blockages. However, not all interactions with the nanopore produce electrical events. They are electrically silent. In order to detect silent events, electrical recordings can be combined with optical measurements. In this work, we evaluate the electrical signatures arising from a number of small molecules and polymers in the alpha hemolysin nanopore. Based on our observations, we categorize the compounds as probable silent translocators, or probable non-translocating blockers. These initial classifications form the basis for paired optical and electrical measurements that will more definitively categorize the event type produced by each molecule." @default.
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- W4319880425 date "2023-02-01" @default.
- W4319880425 modified "2023-09-26" @default.
- W4319880425 title "Analyzing small molecule and polymer events in a protein nanopore for paired optical and electrical measurements" @default.
- W4319880425 doi "https://doi.org/10.1016/j.bpj.2022.11.2778" @default.
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