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- W4319915640 abstract "ABSTRACT Somatosensory information is processed by a complex network of interneurons in the spinal dorsal horn. It has been reported that inhibitory interneurons that express neuropeptide Y (NPY), either permanently or during development, suppress mechanical itch, with no effect on pain. Here we investigate the role of interneurons that continue to express NPY (NPY-INs) in adulthood. We find that chemogenetic activation of NPY-INs reduces behaviours associated with acute pain and pruritogen-evoked itch, whereas silencing them causes exaggerated itch responses that depend on cells expressing the gastrin-releasing peptide receptor. As predicted by our previous studies, silencing of another population of inhibitory interneurons (those expressing dynorphin) also increases itch, but to a lesser extent. Importantly, NPY- IN activation also reduces behavioural signs of inflammatory and neuropathic pain. These results demonstrate that NPY-INs gate pain and itch transmission at the spinal level, and therefore represent a potential treatment target for pathological pain and itch." @default.
- W4319915640 created "2023-02-11" @default.
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- W4319915640 date "2023-02-10" @default.
- W4319915640 modified "2023-09-25" @default.
- W4319915640 title "Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling" @default.
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- W4319915640 doi "https://doi.org/10.1101/2023.02.10.528013" @default.
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