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- W4319916235 abstract "The inward rectifier potassium channel Kir2.1 (KCNJ2) is an important regulator of resting membrane potential in both excitable and non-excitable cells. The function of Kir2.1 channels are dependent on their lipid environment, including the availability of PI(4,5)P2, secondary anionic lipids, cholesterol and long-chain fatty acids acyl coenzyme A (LC-CoA). Endocannabinoids are a class of lipids that are naturally expressed in a variety of cells, including cardiac, neuronal, and immune cells. While these lipids are identified as ligands for cannabinoid receptors (CBRs), there is a growing body of evidence that they can directly regulate the function of numerous ion channels independently of CBRs. Here we examine the effects of a panel of endocannabinoids on Kir2.1 function, and demonstrate that a subset of endocannabinoids can alter Kir2.1 conductance to varying degrees independently of CBRs. These findings may have broader implications on the function of cardiac, neuronal and/or immune cells." @default.
- W4319916235 created "2023-02-11" @default.
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- W4319916235 date "2023-02-01" @default.
- W4319916235 modified "2023-09-30" @default.
- W4319916235 title "Endocannabinoid regulation of inward rectifier (Kir2.1) channels" @default.
- W4319916235 doi "https://doi.org/10.1016/j.bpj.2022.11.2108" @default.
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