FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319937211> ?p ?o ?g. }

• W4319937211 endingPage "19" @default.
• W4319937211 startingPage "1" @default.
• W4319937211 abstract "Background. Diabetic microvascular complications are the main causes of organ dysfunction and even death in diabetic patients. Our previous studies confirmed the beneficial effects of Yiqi Jiedu Huayu Decoction (YJHD) on diabetic cardiomyopathy and diabetic nephropathy. It is not clear whether YJHD can treat multiple diabetic microvascular complications including diabetic retinopathy, diabetic cardiomyopathy, and diabetic nephropathy through some common mechanisms. Methods. TCMSP, SymMap, STITCH, Swiss Target Prediction, and SEA databases were used to collect and analyze the components and targets of YJHD. GeneCards, DrugBank, DisGeNET, OMIM, and GEO databases were used to obtain target genes for diabetic retinopathy, diabetic cardiomyopathy, and diabetic nephropathy. The GO and KEGG enrichment analyses were performed on the DAVID and STRING platforms. Molecular docking was used to evaluate the binding sites and affinities of compounds and target proteins. Animal experiments were designed to validate the network pharmacology results. Results. Through network pharmacological analysis, oxidative stress, inflammatory response, and apoptosis were identified as key pathological phenotypes for the treatment of diabetic microvascular complications with YJHD. In addition, JNK, p38, and ERK1/2 were predicted as key targets of YJHD in regulating the abovementioned pathological phenotypes. The results of animal experiments showed that YJHD could ameliorate retinal pathological changes of diabetes rats. YJHD can inhibit oxidative stress and inflammation in heart and kidney of diabetic rats. Molecular docking showed strong binding between compounds and JNK, p38, and ERK1/2. Berlambine may play a key role in the treatment process and is considered as a promising regulator of MAPK protein family. The regulatory effects of YJHD on JNK, p38, and ERK1/2 were demonstrated in animal experiments. Conclusions. YJHD may play a therapeutic role in diabetic microvascular complications by regulating oxidative stress, inflammatory response, and apoptosis. The regulation of JNK, p38, and ERK1/2 phosphorylation may be the key to its therapeutic effect." @default.
• W4319937211 created "2023-02-11" @default.
• W4319937211 creator A5000939915 @default.
• W4319937211 creator A5014789709 @default.
• W4319937211 creator A5031368952 @default.
• W4319937211 creator A5038267421 @default.
• W4319937211 creator A5056362055 @default.
• W4319937211 creator A5072190113 @default.
• W4319937211 creator A5088726045 @default.
• W4319937211 date "2023-02-10" @default.
• W4319937211 modified "2023-10-17" @default.
• W4319937211 title "Potential Mechanisms of Yiqi Jiedu Huayu Decoction in the Treatment of Diabetic Microvascular Complications Based on Network Analysis, Molecular Docking, and Experimental Validation" @default.
• W4319937211 cites W1531672334 @default.
• W4319937211 cites W1918332591 @default.
• W4319937211 cites W1976422365 @default.
• W4319937211 cites W1983937216 @default.
• W4319937211 cites W1992423152 @default.
• W4319937211 cites W2021343620 @default.
• W4319937211 cites W2038773696 @default.
• W4319937211 cites W2041912799 @default.
• W4319937211 cites W2059467226 @default.
• W4319937211 cites W2060075831 @default.
• W4319937211 cites W2070603512 @default.
• W4319937211 cites W2105731956 @default.
• W4319937211 cites W2118258530 @default.
• W4319937211 cites W2124679671 @default.
• W4319937211 cites W2130213815 @default.
• W4319937211 cites W2134967712 @default.
• W4319937211 cites W2139131794 @default.
• W4319937211 cites W2141485678 @default.
• W4319937211 cites W2145592978 @default.
• W4319937211 cites W2146980885 @default.
• W4319937211 cites W2147684610 @default.
• W4319937211 cites W2148148972 @default.
• W4319937211 cites W2151155970 @default.
• W4319937211 cites W2162011385 @default.
• W4319937211 cites W2162151166 @default.
• W4319937211 cites W2167963794 @default.
• W4319937211 cites W2168938595 @default.
• W4319937211 cites W2176516200 @default.
• W4319937211 cites W2269424011 @default.
• W4319937211 cites W2294516783 @default.
• W4319937211 cites W2398217494 @default.
• W4319937211 cites W2416046640 @default.
• W4319937211 cites W2561206249 @default.
• W4319937211 cites W2561520623 @default.
• W4319937211 cites W2574526323 @default.
• W4319937211 cites W2605955340 @default.
• W4319937211 cites W2766417776 @default.
• W4319937211 cites W2767338841 @default.
• W4319937211 cites W2767891136 @default.
• W4319937211 cites W2783967092 @default.
• W4319937211 cites W2791517164 @default.
• W4319937211 cites W2899291554 @default.
• W4319937211 cites W2916667086 @default.
• W4319937211 cites W2950764390 @default.
• W4319937211 cites W2963199063 @default.
• W4319937211 cites W2979960563 @default.
• W4319937211 cites W2983166786 @default.
• W4319937211 cites W3098935468 @default.
• W4319937211 cites W3107527779 @default.
• W4319937211 cites W3153883206 @default.
• W4319937211 cites W3156147612 @default.
• W4319937211 cites W3165593994 @default.
• W4319937211 cites W3183548861 @default.
• W4319937211 cites W3199276942 @default.
• W4319937211 cites W4220831425 @default.
• W4319937211 cites W4229441067 @default.
• W4319937211 cites W4248107770 @default.
• W4319937211 cites W565001682 @default.
• W4319937211 doi "https://doi.org/10.1155/2023/5034687" @default.
• W4319937211 hasPublicationYear "2023" @default.
• W4319937211 type Work @default.
• W4319937211 citedByCount "0" @default.
• W4319937211 crossrefType "journal-article" @default.
• W4319937211 hasAuthorship W4319937211A5000939915 @default.
• W4319937211 hasAuthorship W4319937211A5014789709 @default.
• W4319937211 hasAuthorship W4319937211A5031368952 @default.
• W4319937211 hasAuthorship W4319937211A5038267421 @default.
• W4319937211 hasAuthorship W4319937211A5056362055 @default.
• W4319937211 hasAuthorship W4319937211A5072190113 @default.
• W4319937211 hasAuthorship W4319937211A5088726045 @default.
• W4319937211 hasBestOaLocation W43199372111 @default.
• W4319937211 hasConcept C126322002 @default.
• W4319937211 hasConcept C134018914 @default.
• W4319937211 hasConcept C155261790 @default.
• W4319937211 hasConcept C2776151105 @default.
• W4319937211 hasConcept C2776553924 @default.
• W4319937211 hasConcept C2778198053 @default.
• W4319937211 hasConcept C2778797674 @default.
• W4319937211 hasConcept C2779829184 @default.
• W4319937211 hasConcept C2779922275 @default.
• W4319937211 hasConcept C2780035454 @default.
• W4319937211 hasConcept C2781184683 @default.
• W4319937211 hasConcept C555293320 @default.
• W4319937211 hasConcept C60644358 @default.
• W4319937211 hasConcept C71924100 @default.
• W4319937211 hasConcept C86803240 @default.

• next