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• W4319959946 startingPage "236" @default.
• W4319959946 abstract "Histoplasma capsulatum, the etiological agent for histoplasmosis, is a dimorphic fungus that grows as a mold in the environment and as a yeast in human tissues. The areas of highest endemicity lie within the Mississippi and Ohio River Valleys of North America and parts of Central and South America. The most common clinical presentations include pulmonary histoplasmosis, which can resemble community-acquired pneumonia, tuberculosis, sarcoidosis, or malignancy; however, certain patients can develop mediastinal involvement or progression to disseminated disease. Understanding the epidemiology, pathology, clinical presentation, and diagnostic testing performance is pivotal for a successful diagnosis. While most immunocompetent patients with mild acute or subacute pulmonary histoplasmosis should receive therapy, all immunocompromised patients and those with chronic pulmonary disease or progressive disseminated disease should also receive therapy. Liposomal amphotericin B is the agent of choice for severe or disseminated disease, and itraconazole is recommended in milder cases or as “step-down” therapy after initial improvement with amphotericin B. In this review, we discuss the current epidemiology, pathology, diagnosis, clinical presentations, and management of pulmonary histoplasmosis." @default.
• W4319959946 created "2023-02-11" @default.
• W4319959946 creator A5028728138 @default.
• W4319959946 creator A5068425096 @default.
• W4319959946 creator A5072895969 @default.
• W4319959946 date "2023-02-10" @default.
• W4319959946 modified "2023-09-26" @default.
• W4319959946 title "Pulmonary Histoplasmosis: A Clinical Update" @default.
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