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- W4319963644 abstract "As the ultimate output of gene expression, proteins are critical in our understanding of the multitude of biological processes that define cellular function. The collection of proteins, or the proteome, in the human body is estimated to contain over 20,000 unique molecules that interact among each other and other biological molecules such as RNA in many ways. The coordination of protein behaviors necessitates global surveying of their abundances, as opposed to traditional methods that are limited in measuring only dozens of proteins. The measurement of thousands of proteins in tandem has been enabled by the advancing technology of mass spectrometry coupled with liquid chromatography. The advent of single-cell resolution global protein measurements - which was once thought to be impossible by several experts - has further expanded the field, with increasing throughput and accuracy. The purpose of this thesis is to call attention to the needed accessibility of single-cell proteomics and applying the technology to the earliest stages of mammalian development to understand the extent of heterogeneity within the embryo when it is composed of just a few cells. Additionally, the importance of investigating the fundamental cellular machine that synthesizes proteins, the ribosome, through the use of complementary mass spectrometry methods and in the context of immune cells will be explored. Overall, this thesis aims to establish the significant role of mass spectrometry methods which enable the discovery of a novel molecular signature in the first stages of mammalian life and the observation of differential ribosomal protein abundance in human immune cells. --Author's abstract" @default.
- W4319963644 created "2023-02-11" @default.
- W4319963644 creator A5083537841 @default.
- W4319963644 date "2023-02-10" @default.
- W4319963644 modified "2023-09-30" @default.
- W4319963644 title "Quantifying protein modulation in mammalian development and ribosome specialization using mass spectrometry" @default.
- W4319963644 doi "https://doi.org/10.17760/d20474747" @default.
- W4319963644 hasPublicationYear "2023" @default.
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