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- W4319983072 endingPage "3547" @default.
- W4319983072 startingPage "3547" @default.
- W4319983072 abstract "Cancer treatment evokes impediments to liver metabolism that culminate in fatty liver. This study determined hepatic fatty acid composition and expression of genes and mediators involved in lipid metabolism following chemotherapy treatment. Female rats bearing the Ward colon tumor were administered Irinotecan (CPT-11) +5-fluorouracil (5-FU) and maintained on a control diet or a diet containing eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) (2.3 g/100 g fish oil). Healthy animals provided with a control diet served as a reference group. Livers were collected one week after chemotherapy. Triacylglycerol (TG), phospholipid (PL), ten lipid metabolism genes, leptin, and IL-4 were measured. Chemotherapy increased TG content and reduced EPA content in the liver. Expression of SCD1 was upregulated by chemotherapy, while dietary fish oil downregulated its expression. Dietary fish oil down-regulated expression of the fatty acid synthesis gene FASN, while restoring the long chain fatty acid converting genes FADS2 and ELOVL2, and genes involved in mitochondrial β-oxidation (CPT1α) and lipid transport (MTTP1), to values similar to reference animals. Neither leptin nor IL-4 were affected by chemotherapy or diet. Depletion of EPA is associated with pathways evoking enhanced TG accumulation in the liver. Restoring EPA through diet may pose a dietary strategy to attenuate chemotherapy-associated impediments in liver fatty acid metabolism." @default.
- W4319983072 created "2023-02-11" @default.
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- W4319983072 date "2023-02-10" @default.
- W4319983072 modified "2023-10-10" @default.
- W4319983072 title "Increased Expression of Hepatic Stearoyl-CoA Desaturase (SCD)-1 and Depletion of Eicosapentaenoic Acid (EPA) Content following Cytotoxic Cancer Therapy Are Reversed by Dietary Fish Oil" @default.
- W4319983072 cites W1497854044 @default.
- W4319983072 cites W1817964822 @default.
- W4319983072 cites W1964113171 @default.
- W4319983072 cites W1965589699 @default.
- W4319983072 cites W1968872717 @default.
- W4319983072 cites W1972806009 @default.
- W4319983072 cites W1976184013 @default.
- W4319983072 cites W1978727574 @default.
- W4319983072 cites W1985280375 @default.
- W4319983072 cites W1996775250 @default.
- W4319983072 cites W1999617321 @default.
- W4319983072 cites W1999893781 @default.
- W4319983072 cites W2000275607 @default.
- W4319983072 cites W2001513552 @default.
- W4319983072 cites W2003512204 @default.
- W4319983072 cites W2003601851 @default.
- W4319983072 cites W2006162642 @default.
- W4319983072 cites W2007887164 @default.
- W4319983072 cites W2013156763 @default.
- W4319983072 cites W2016526435 @default.
- W4319983072 cites W2026887934 @default.
- W4319983072 cites W2030532669 @default.
- W4319983072 cites W2032779971 @default.
- W4319983072 cites W203580716 @default.
- W4319983072 cites W2035877503 @default.
- W4319983072 cites W2040713811 @default.
- W4319983072 cites W2045084840 @default.
- W4319983072 cites W2050792354 @default.
- W4319983072 cites W2052981488 @default.
- W4319983072 cites W2061852823 @default.
- W4319983072 cites W2068075000 @default.
- W4319983072 cites W2073881958 @default.
- W4319983072 cites W2077390673 @default.
- W4319983072 cites W2079378050 @default.
- W4319983072 cites W2080725795 @default.
- W4319983072 cites W2091217847 @default.
- W4319983072 cites W2099074546 @default.
- W4319983072 cites W2099110406 @default.
- W4319983072 cites W2104945088 @default.
- W4319983072 cites W2106269708 @default.
- W4319983072 cites W2113208048 @default.
- W4319983072 cites W2113332979 @default.
- W4319983072 cites W2116283917 @default.
- W4319983072 cites W2118624226 @default.
- W4319983072 cites W2130006555 @default.
- W4319983072 cites W2130618859 @default.
- W4319983072 cites W2134859900 @default.
- W4319983072 cites W2140809734 @default.
- W4319983072 cites W2152209571 @default.
- W4319983072 cites W2155151130 @default.
- W4319983072 cites W2166165585 @default.
- W4319983072 cites W2168526937 @default.
- W4319983072 cites W2168987774 @default.
- W4319983072 cites W2182863637 @default.
- W4319983072 cites W2400144561 @default.
- W4319983072 cites W2530564279 @default.
- W4319983072 cites W2735867008 @default.
- W4319983072 cites W2749051880 @default.
- W4319983072 cites W2770903823 @default.
- W4319983072 cites W2792374913 @default.
- W4319983072 cites W2794266645 @default.
- W4319983072 cites W2803173125 @default.
- W4319983072 cites W2808266097 @default.
- W4319983072 cites W2810423511 @default.
- W4319983072 cites W2889508718 @default.
- W4319983072 cites W2901872961 @default.
- W4319983072 cites W2904806538 @default.
- W4319983072 cites W2921570078 @default.
- W4319983072 cites W2952100543 @default.
- W4319983072 cites W2974754926 @default.
- W4319983072 cites W3001608359 @default.
- W4319983072 cites W3026486594 @default.
- W4319983072 cites W3047322838 @default.
- W4319983072 cites W3103318027 @default.
- W4319983072 cites W3119800889 @default.
- W4319983072 cites W3134118467 @default.
- W4319983072 cites W3176134575 @default.
- W4319983072 cites W3180380581 @default.
- W4319983072 cites W3188472070 @default.
- W4319983072 cites W3209855576 @default.
- W4319983072 cites W4211224332 @default.
- W4319983072 cites W4234590780 @default.
- W4319983072 doi "https://doi.org/10.3390/ijms24043547" @default.
- W4319983072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36834959" @default.
- W4319983072 hasPublicationYear "2023" @default.
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