Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319983316> ?p ?o ?g. }
- W4319983316 endingPage "3473" @default.
- W4319983316 startingPage "3473" @default.
- W4319983316 abstract "BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) is a transmembrane pseudoreceptor structurally related to transforming growth factor (TGF)-β type 1 receptors (TGF-β1Rs). BAMBI lacks a kinase domain and functions as a TGF-β1R antagonist. Essential processes such as cell differentiation and proliferation are regulated by TGF-β1R signaling. TGF-β is the best-studied ligand of TGF-βRs and has an eminent role in inflammation and fibrogenesis. Liver fibrosis is the end stage of almost all chronic liver diseases, such as non-alcoholic fatty liver disease, and at the moment, there is no effective anti-fibrotic therapy available. Hepatic BAMBI is downregulated in rodent models of liver injury and in the fibrotic liver of patients, suggesting that low BAMBI has a role in liver fibrosis. Experimental evidence convincingly demonstrated that BAMBI overexpression is able to protect against liver fibrosis. Chronic liver diseases have a high risk of hepatocellular carcinoma (HCC), and BAMBI was shown to exert tumor-promoting as well as tumor-protective functions. This review article aims to summarize relevant studies on hepatic BAMBI expression and its role in chronic liver diseases and HCC." @default.
- W4319983316 created "2023-02-11" @default.
- W4319983316 creator A5039350368 @default.
- W4319983316 creator A5059126107 @default.
- W4319983316 creator A5075612423 @default.
- W4319983316 creator A5087151081 @default.
- W4319983316 date "2023-02-09" @default.
- W4319983316 modified "2023-09-25" @default.
- W4319983316 title "Expression and Function of BMP and Activin Membrane-Bound Inhibitor (BAMBI) in Chronic Liver Diseases and Hepatocellular Carcinoma" @default.
- W4319983316 cites W1504064570 @default.
- W4319983316 cites W1520585165 @default.
- W4319983316 cites W1526931309 @default.
- W4319983316 cites W1666089077 @default.
- W4319983316 cites W1806907787 @default.
- W4319983316 cites W1964862537 @default.
- W4319983316 cites W1967442057 @default.
- W4319983316 cites W1969729024 @default.
- W4319983316 cites W1971010914 @default.
- W4319983316 cites W1975551419 @default.
- W4319983316 cites W1976509021 @default.
- W4319983316 cites W1982608239 @default.
- W4319983316 cites W1986960611 @default.
- W4319983316 cites W1987705287 @default.
- W4319983316 cites W1990768683 @default.
- W4319983316 cites W1993428261 @default.
- W4319983316 cites W1996266503 @default.
- W4319983316 cites W1996852201 @default.
- W4319983316 cites W1998138748 @default.
- W4319983316 cites W2000716829 @default.
- W4319983316 cites W2001614274 @default.
- W4319983316 cites W2003487524 @default.
- W4319983316 cites W2006307216 @default.
- W4319983316 cites W2007489122 @default.
- W4319983316 cites W2008104067 @default.
- W4319983316 cites W2008318902 @default.
- W4319983316 cites W2011211995 @default.
- W4319983316 cites W2014198756 @default.
- W4319983316 cites W2014533420 @default.
- W4319983316 cites W2022823035 @default.
- W4319983316 cites W2025383646 @default.
- W4319983316 cites W2029194147 @default.
- W4319983316 cites W2029634411 @default.
- W4319983316 cites W2029818077 @default.
- W4319983316 cites W2032211678 @default.
- W4319983316 cites W2038189901 @default.
- W4319983316 cites W2042571415 @default.
- W4319983316 cites W2042967938 @default.
- W4319983316 cites W2046775810 @default.
- W4319983316 cites W2050345976 @default.
- W4319983316 cites W2051399737 @default.
- W4319983316 cites W2053367250 @default.
- W4319983316 cites W2056376819 @default.
- W4319983316 cites W2060343419 @default.
- W4319983316 cites W2061403592 @default.
- W4319983316 cites W2061866473 @default.
- W4319983316 cites W2067485085 @default.
- W4319983316 cites W2067968257 @default.
- W4319983316 cites W2070366583 @default.
- W4319983316 cites W2071937747 @default.
- W4319983316 cites W2073438109 @default.
- W4319983316 cites W2073743007 @default.
- W4319983316 cites W2074078019 @default.
- W4319983316 cites W2076652911 @default.
- W4319983316 cites W2077062607 @default.
- W4319983316 cites W2078052857 @default.
- W4319983316 cites W2080620816 @default.
- W4319983316 cites W2084722601 @default.
- W4319983316 cites W2084875520 @default.
- W4319983316 cites W2087367170 @default.
- W4319983316 cites W2091245443 @default.
- W4319983316 cites W2091876682 @default.
- W4319983316 cites W2095866442 @default.
- W4319983316 cites W2097349104 @default.
- W4319983316 cites W2101547995 @default.
- W4319983316 cites W2107274741 @default.
- W4319983316 cites W2107500412 @default.
- W4319983316 cites W2116707190 @default.
- W4319983316 cites W2134058536 @default.
- W4319983316 cites W2137592087 @default.
- W4319983316 cites W2138202219 @default.
- W4319983316 cites W2141674000 @default.
- W4319983316 cites W2151429631 @default.
- W4319983316 cites W2153013045 @default.
- W4319983316 cites W2155259249 @default.
- W4319983316 cites W2156808480 @default.
- W4319983316 cites W2160615487 @default.
- W4319983316 cites W2160638574 @default.
- W4319983316 cites W2164906049 @default.
- W4319983316 cites W2169231894 @default.
- W4319983316 cites W2170845559 @default.
- W4319983316 cites W2171420088 @default.
- W4319983316 cites W2172267451 @default.
- W4319983316 cites W2182150538 @default.
- W4319983316 cites W2219242871 @default.
- W4319983316 cites W2239195368 @default.
- W4319983316 cites W2256103742 @default.
- W4319983316 cites W2305686027 @default.
- W4319983316 cites W2340761255 @default.