Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319983908> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4319983908 abstract "Background: The extracts of Annona muricata, also known as graviola, form part of traditional medicine.
 Objectives: Verification of their effects and elucidation of their mechanisms is beneficial in terms of the utility of these extracts in treatment or prevention.
 Methods: We monitored the effectiveness of an extract of dried graviola leaves available for direct consumption on cancer cell lines and isolated rat liver mitochondria.
 Results: The Jurkat cell line exhibited the highest, sensitivity, with the metabolic activity of cells reaching less than 10% at the highest tested concentration. The effect was dose-dependent. The viability of Jurkat cells was affected after more than the 72 hours. At the same time, there was also a reduction of mitochondrial membrane potential. At 24 to 48 hours incubation, no increase was found in the activity of caspase-3 but increased levels were found for the non-phosphorylated form of Bcl-2. Higher concentrations of graviola affected the mitochondrial redox state by dramatically reducing the levels of reduced glutathione. This was achieved through reduction in the activity of glutathione-S-transferase.
 Conclusion: Our findings indicate that the studied preparation of graviola displayed cytotoxic effects on some cells, depending on the dose and length of action.
" @default.
- W4319983908 created "2023-02-11" @default.
- W4319983908 creator A5010313809 @default.
- W4319983908 creator A5019354149 @default.
- W4319983908 creator A5033398331 @default.
- W4319983908 creator A5042688098 @default.
- W4319983908 creator A5091847495 @default.
- W4319983908 date "2022-01-12" @default.
- W4319983908 modified "2023-10-17" @default.
- W4319983908 title "Assessment of the effects of Annona muricata leaf aqueous extract in vitro" @default.
- W4319983908 doi "https://doi.org/10.9755/ejfa.2021.v33.i11.2785" @default.
- W4319983908 hasPublicationYear "2022" @default.
- W4319983908 type Work @default.
- W4319983908 citedByCount "0" @default.
- W4319983908 crossrefType "journal-article" @default.
- W4319983908 hasAuthorship W4319983908A5010313809 @default.
- W4319983908 hasAuthorship W4319983908A5019354149 @default.
- W4319983908 hasAuthorship W4319983908A5033398331 @default.
- W4319983908 hasAuthorship W4319983908A5042688098 @default.
- W4319983908 hasAuthorship W4319983908A5091847495 @default.
- W4319983908 hasBestOaLocation W43199839081 @default.
- W4319983908 hasConcept C179464577 @default.
- W4319983908 hasConcept C181199279 @default.
- W4319983908 hasConcept C185592680 @default.
- W4319983908 hasConcept C202751555 @default.
- W4319983908 hasConcept C203014093 @default.
- W4319983908 hasConcept C2776090121 @default.
- W4319983908 hasConcept C2779565439 @default.
- W4319983908 hasConcept C538909803 @default.
- W4319983908 hasConcept C54355233 @default.
- W4319983908 hasConcept C55493867 @default.
- W4319983908 hasConcept C59822182 @default.
- W4319983908 hasConcept C81885089 @default.
- W4319983908 hasConcept C86803240 @default.
- W4319983908 hasConcept C8891405 @default.
- W4319983908 hasConceptScore W4319983908C179464577 @default.
- W4319983908 hasConceptScore W4319983908C181199279 @default.
- W4319983908 hasConceptScore W4319983908C185592680 @default.
- W4319983908 hasConceptScore W4319983908C202751555 @default.
- W4319983908 hasConceptScore W4319983908C203014093 @default.
- W4319983908 hasConceptScore W4319983908C2776090121 @default.
- W4319983908 hasConceptScore W4319983908C2779565439 @default.
- W4319983908 hasConceptScore W4319983908C538909803 @default.
- W4319983908 hasConceptScore W4319983908C54355233 @default.
- W4319983908 hasConceptScore W4319983908C55493867 @default.
- W4319983908 hasConceptScore W4319983908C59822182 @default.
- W4319983908 hasConceptScore W4319983908C81885089 @default.
- W4319983908 hasConceptScore W4319983908C86803240 @default.
- W4319983908 hasConceptScore W4319983908C8891405 @default.
- W4319983908 hasLocation W43199839081 @default.
- W4319983908 hasOpenAccess W4319983908 @default.
- W4319983908 hasPrimaryLocation W43199839081 @default.
- W4319983908 hasRelatedWork W146368943 @default.
- W4319983908 hasRelatedWork W2009835339 @default.
- W4319983908 hasRelatedWork W2013803490 @default.
- W4319983908 hasRelatedWork W2040793287 @default.
- W4319983908 hasRelatedWork W2355622847 @default.
- W4319983908 hasRelatedWork W2419373430 @default.
- W4319983908 hasRelatedWork W2770846884 @default.
- W4319983908 hasRelatedWork W2915648405 @default.
- W4319983908 hasRelatedWork W3148570401 @default.
- W4319983908 hasRelatedWork W4200160080 @default.
- W4319983908 isParatext "false" @default.
- W4319983908 isRetracted "false" @default.
- W4319983908 workType "article" @default.