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• W4319984037 abstract "Fibrosis affects millions of people with cardiac disease. We developed a therapeutic approach to generate transient antifibrotic chimeric antigen receptor (CAR) T cells in vivo by delivering modified messenger RNA (mRNA) in T cell–targeted lipid nanoparticles (LNPs). The efficacy of these in vivo–reprogrammed CAR T cells was evaluated by injecting CD5-targeted LNPs into a mouse model of heart failure. Efficient delivery of modified mRNA encoding the CAR to T lymphocytes was observed, which produced transient, effective CAR T cells in vivo. Antifibrotic CAR T cells exhibited trogocytosis and retained the target antigen as they accumulated in the spleen. Treatment with modified mRNA-targeted LNPs reduced fibrosis and restored cardiac function after injury. In vivo generation of CAR T cells may hold promise as a therapeutic platform to treat various diseases." @default.
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• W4319984037 date "2023-02-09" @default.
• W4319984037 modified "2023-09-29" @default.
• W4319984037 title "CAR T Cells Produced in vivo to Treat Cardiac Injury" @default.
• W4319984037 doi "https://doi.org/10.9734/bpi/mono/978-81-19039-63-0/ch19" @default.
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