Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319985003> ?p ?o ?g. }
- W4319985003 abstract "Brain size is controlled by several factors during neuronal development, including neural progenitor proliferation, neuronal arborization, gliogenesis, cell death, and synaptogenesis. Multiple neurodevelopmental disorders have co-morbid brain size abnormalities, such as microcephaly and macrocephaly. Mutations in histone methyltransferases that modify histone H3 on Lysine 36 and Lysine 4 (H3K36 and H3K4) have been identified in neurodevelopmental disorders involving both microcephaly and macrocephaly. H3K36 and H3K4 methylation are both associated with transcriptional activation and are proposed to sterically hinder the repressive activity of the Polycomb Repressor Complex 2 (PRC2). During neuronal development, tri-methylation of H3K27 (H3K27me3) by PRC2 leads to genome wide transcriptional repression of genes that regulate cell fate transitions and neuronal arborization. Here we provide a review of neurodevelopmental processes and disorders associated with H3K36 and H3K4 histone methyltransferases, with emphasis on processes that contribute to brain size abnormalities. Additionally, we discuss how the counteracting activities of H3K36 and H3K4 modifying enzymes vs. PRC2 could contribute to brain size abnormalities which is an underexplored mechanism in relation to brain size control." @default.
- W4319985003 created "2023-02-11" @default.
- W4319985003 creator A5036110952 @default.
- W4319985003 creator A5073398502 @default.
- W4319985003 date "2023-02-10" @default.
- W4319985003 modified "2023-09-26" @default.
- W4319985003 title "The role of histone methyltransferases in neurocognitive disorders associated with brain size abnormalities" @default.
- W4319985003 cites W1492349549 @default.
- W4319985003 cites W1516412274 @default.
- W4319985003 cites W1517391732 @default.
- W4319985003 cites W1562967551 @default.
- W4319985003 cites W1596340390 @default.
- W4319985003 cites W1660108428 @default.
- W4319985003 cites W1870702458 @default.
- W4319985003 cites W1918697652 @default.
- W4319985003 cites W1961487924 @default.
- W4319985003 cites W1964096828 @default.
- W4319985003 cites W1964444099 @default.
- W4319985003 cites W1968135430 @default.
- W4319985003 cites W1969451832 @default.
- W4319985003 cites W1971782340 @default.
- W4319985003 cites W1972343220 @default.
- W4319985003 cites W1972546951 @default.
- W4319985003 cites W1974573196 @default.
- W4319985003 cites W1975534977 @default.
- W4319985003 cites W1976231145 @default.
- W4319985003 cites W1981173248 @default.
- W4319985003 cites W1987855481 @default.
- W4319985003 cites W1988670106 @default.
- W4319985003 cites W1989851471 @default.
- W4319985003 cites W1989878674 @default.
- W4319985003 cites W1991097863 @default.
- W4319985003 cites W1995030818 @default.
- W4319985003 cites W1996358062 @default.
- W4319985003 cites W1997500462 @default.
- W4319985003 cites W1997698058 @default.
- W4319985003 cites W1998642080 @default.
- W4319985003 cites W2002858128 @default.
- W4319985003 cites W2004944757 @default.
- W4319985003 cites W2008627757 @default.
- W4319985003 cites W2008735740 @default.
- W4319985003 cites W2009742334 @default.
- W4319985003 cites W2010915225 @default.
- W4319985003 cites W2010994321 @default.
- W4319985003 cites W2011430819 @default.
- W4319985003 cites W2013052085 @default.
- W4319985003 cites W2014077036 @default.
- W4319985003 cites W2014359105 @default.
- W4319985003 cites W2015416439 @default.
- W4319985003 cites W2015964634 @default.
- W4319985003 cites W2016024994 @default.
- W4319985003 cites W2020472917 @default.
- W4319985003 cites W2021456334 @default.
- W4319985003 cites W2021515035 @default.
- W4319985003 cites W2024052509 @default.
- W4319985003 cites W2025843782 @default.
- W4319985003 cites W2028251241 @default.
- W4319985003 cites W2029064689 @default.
- W4319985003 cites W2030615857 @default.
- W4319985003 cites W2032850366 @default.
- W4319985003 cites W2036533995 @default.
- W4319985003 cites W2039201797 @default.
- W4319985003 cites W2040675004 @default.
- W4319985003 cites W2044161108 @default.
- W4319985003 cites W2045042214 @default.
- W4319985003 cites W2046337021 @default.
- W4319985003 cites W2046927137 @default.
- W4319985003 cites W2050350831 @default.
- W4319985003 cites W2054205113 @default.
- W4319985003 cites W2054408230 @default.
- W4319985003 cites W2057202901 @default.
- W4319985003 cites W2057203744 @default.
- W4319985003 cites W2057308155 @default.
- W4319985003 cites W2061445259 @default.
- W4319985003 cites W2061793726 @default.
- W4319985003 cites W2063103796 @default.
- W4319985003 cites W2063130944 @default.
- W4319985003 cites W2064382418 @default.
- W4319985003 cites W2067416991 @default.
- W4319985003 cites W2068943457 @default.
- W4319985003 cites W2072577103 @default.
- W4319985003 cites W2074838566 @default.
- W4319985003 cites W2074917365 @default.
- W4319985003 cites W2075327666 @default.
- W4319985003 cites W2075846203 @default.
- W4319985003 cites W2077630079 @default.
- W4319985003 cites W2079175475 @default.
- W4319985003 cites W2086046991 @default.
- W4319985003 cites W2086906637 @default.
- W4319985003 cites W2087216143 @default.
- W4319985003 cites W2089924497 @default.
- W4319985003 cites W2091117014 @default.
- W4319985003 cites W2091376817 @default.
- W4319985003 cites W2091579735 @default.
- W4319985003 cites W2091605994 @default.
- W4319985003 cites W2092767791 @default.
- W4319985003 cites W2094074562 @default.
- W4319985003 cites W2096149923 @default.
- W4319985003 cites W2099818637 @default.
- W4319985003 cites W2100663971 @default.