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- W4319990537 abstract "Epilepsy is a diverse group of brain disorders mainly defined by recurrent seizures. Precise localization of epileptic activity in the cerebral cortex and subcortical structures is a complex problem that usually requires a host of methods such as electroencephalography (EEG), magnetic resonance imaging (MRI), and positron emission tomography (PET) in clinical studies. From the end of the previous century, optical imaging methods have yielded revolutionary results when applied to all parts of the brain. In this chapter we cover intrinsic optical imaging and voltage-sensitive dye imaging, as well as several other techniques. All optical imaging techniques reflect various physiological processes in brain tissue which are indissolubly related with neuronal processes. While all the discussed imaging methods are applicable to animal models, several of them can also be used in human medicine for clinical studies and diagnostics. The basic principles of optical imaging of intrinsic signal, voltage-sensitive dye imaging, functional near-infrared spectroscopy, photoacoustic and their variations are described, followed by examples of cutting-edge epileptic studies where they have been utilized. In contrast to PET and fMRI, the main limitation of optical imaging is the limited penetration of photons, which allows us to only image cortical structures no deeper than a few tenths of a millimeter. Advantages include high spatial (up to microns) and temporal (up to milliseconds) resolution and relatively low costs. Scientists and clinicians employ a variety of optical imaging technologies to visualize and study the relationship between neurons, glial cells, and blood vessels. In this chapter we present an overview of the current optical approaches used for the in vivo imaging of epileptic seizures." @default.
- W4319990537 created "2023-02-11" @default.
- W4319990537 creator A5060637913 @default.
- W4319990537 date "2023-01-01" @default.
- W4319990537 modified "2023-10-16" @default.
- W4319990537 title "Optical Imaging of Epileptic Seizures" @default.
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