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- W4320000590 endingPage "122" @default.
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- W4320000590 abstract "The transition from one-celled zygote to early embryogenesis and beyond is a delicately orchestrated interplay of transcription factors and epigenetic changes. These epigenetic changes can be in the form of DNA methylation or the addition of substituents on specific histone residues and ultimately involve a change in chromatin structure. The changes are aided by the chromatin remodeling complex to bring about the desired cellular and molecular changes. The epigenetic machinery broadly consists of PcG and Trx proteins which act antagonistically to each other. The pluripotent ESCs are characterized by a distinct set of epigenetic features which act together to maintain their self-renewal and differentiating properties. A prominent epigenetic characteristic feature is H3K4me3-enriched promoters of pluripotency genes which promote gene transcription. Some of these promoters may also contain a repressive mark such as H3K27me3. These regions are called bivalent domains and enable stricter regulation. ESCs, after differentiation, generate MSCs. MSCs have their own distinct core epigenetic patterns which govern homeostasis and differentiation into specific lineages. Here, we discuss the different players in epigenetic modification and their role in the maintenance of stemness and differentiation in ESCs and MSCs." @default.
- W4320000590 created "2023-02-11" @default.
- W4320000590 creator A5014642479 @default.
- W4320000590 creator A5048011810 @default.
- W4320000590 creator A5056416573 @default.
- W4320000590 date "2023-01-01" @default.
- W4320000590 modified "2023-09-29" @default.
- W4320000590 title "Epigenetic signatures that maintain stemness in pluripotent and mesenchymal stem cells" @default.
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