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- W4320001043 abstract "The excitatory effects can be induced by increase in gut microbial tryptamine that interacts with glutamate receptors, but in contrast to glutamate, readily crosses the blood-brain barrier. Glutamate receptors and transporters mediate and modulate tryptamine activity. Tryptamine and some other biogenic amines are implicated in glutamate signaling impaired in AD Our data demonstrate that saturation concentrations for tryptophan and glutamic acid in reaction of tRNA aminoacylation directly correlate with availability of these amino acids in humans for protein biosynthesis. Tryptophan, the least available amino acid from the diet, and proteins demonstrated the lower saturation concentration in the first step of protein biosynthesis tRNA aminoacylation compared to such for the abundant amino acid glutamic acid (codon frequency for Trp 1.3% and for Glu 5.8%). Tryptamine inhibits transport of the glutamate metabolite GABA via PAT1 amino acid transport system. Glutamate is an important neurotransmitter in vagal signaling that can be implicated in irritable bowel syndrome, while monosodium glutamate used as a food component may play a trigger role in irritable bowel syndrome, in which the gut microbial tryptamine is elevated." @default.
- W4320001043 created "2023-02-11" @default.
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- W4320001043 date "2023-01-01" @default.
- W4320001043 modified "2023-09-25" @default.
- W4320001043 title "Glutamate and glutamate receptors in vagus nerve pathways and in Alzheimer’s disease" @default.
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