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- W4320002533 abstract "The human cornea is a highly organized connective tissue composed of collagen fibers, proteoglycans, interstitial fluid, and specialized cells, with unique mechanical properties that enable refraction of light while withstanding the intraocular pressure. The mechanical properties of cornea can be altered and disrupted in disease such as keratoconus and following surgical interventions including laser-assisted in situ keratomileusis and photorefractive keratectomy surgery. In silico modeling and simulation offers great potential to advance our knowledge of corneal biomechanics in healthy and disease states by providing a cost- and time-effective approach through virtual experiments. Recent progress in computational modeling of corneal mechanics has enabled the preoperative screening of cornea for refractive surgery and provided the promise for prevention and early diagnosis of multiple corneal pathologies. In this chapter, after a brief introduction to corneal anatomy, physiology, and biomechanics, we will review the recent advances in computational modeling of corneal mechanics and potential applications of cornea digital twins in disease prevention, diagnosis, management, and prediction of surgical outcomes." @default.
- W4320002533 created "2023-02-11" @default.
- W4320002533 creator A5054261269 @default.
- W4320002533 date "2023-01-01" @default.
- W4320002533 modified "2023-09-30" @default.
- W4320002533 title "Cornea digital twins for studying the critical role of mechanics in physiology, pathology and surgical repair" @default.
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- W4320002533 doi "https://doi.org/10.1016/b978-0-12-823913-1.00017-8" @default.
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