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- W4320006543 abstract "Droxidopa (L-threo-3,4-dihydroxyphenyl-serine, L-DOPS) is an oral synthetic amino acid that is converted to the naturally occurring sympathetic neurotransmitter norepinephrine, in a reaction mediated by the enzyme dopa-decarboxylase. After large placebo-controlled trials showed that it was safe and effective to reduce symptoms and increase blood pressure when standing, droxidopa was approved in 2014 in the United States for the treatment of neurogenic orthostatic hypotension (nOH) caused by Parkinson disease (PD), multiple system atrophy (MSA), pure autonomic failure (PAF), and nondiabetic autonomic neuropathies. Since then, droxidopa has been used by thousands of patients and its safety and tolerability in periods longer than the ones tested in the clinical trials have been documented. Recent studies have identified biomarkers that predict what patients with nOH are most likely to respond to droxidopa." @default.
- W4320006543 created "2023-02-11" @default.
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- W4320006543 date "2023-01-01" @default.
- W4320006543 modified "2023-10-18" @default.
- W4320006543 title "Droxidopa" @default.
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- W4320006543 doi "https://doi.org/10.1016/b978-0-323-85492-4.00022-3" @default.
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