FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320032904> ?p ?o ?g. }

• W4320032904 endingPage "3670" @default.
• W4320032904 startingPage "3650" @default.
• W4320032904 abstract "Epithelial mesenchymal plasticity (EMP) is a complex cellular reprogramming event that plays a major role in tissue homeostasis. Recently we observed the unfolded protein response (UPR) triggers EMP through the inositol-requiring protein 1 (IRE1α)-X-box-binding protein 1 spliced (XBP1s) axis, enhancing glucose shunting to protein N glycosylation. To better understand the genomic targets of XBP1s, we identified its genomic targets using Cleavage Under Targets and Release Using Nuclease (CUT&RUN) of a FLAG-epitope tagged XBP1s in RSV infection. CUT&RUN identified 7086 binding sites in chromatin that were enriched in AP-1 motifs and GC-sequences. Of these binding sites, XBP1s peaks mapped to 4827 genes controlling Rho-GTPase signaling, N-linked glycosylation and ER-Golgi transport. Strikingly, XBP1s peaks were within 1 kb of transcription start sites of 2119 promoters. In addition to binding core mesenchymal transcription factors SNAI1 and ZEB1, we observed that hexosamine biosynthetic pathway (HBP) enzymes were induced and contained proximal XBP1s peaks. We demonstrate that IRE1α -XBP1s signaling is necessary and sufficient to activate core enzymes by recruiting elongation-competent phospho-Ser2 CTD modified RNA Pol II. We conclude that the IRE1α-XBP1s pathway coordinately regulates mesenchymal transcription factors and hexosamine biosynthesis in EMP by a mechanism involving recruitment of activated pSer2-Pol II to GC-rich promoters." @default.
• W4320032904 created "2023-02-12" @default.
• W4320032904 creator A5013617011 @default.
• W4320032904 creator A5048097785 @default.
• W4320032904 creator A5056656832 @default.
• W4320032904 creator A5058325475 @default.
• W4320032904 date "2023-02-11" @default.
• W4320032904 modified "2023-10-12" @default.
• W4320032904 title "Genomic targets of the IRE1-XBP1s pathway in mediating metabolic adaptation in epithelial plasticity" @default.
• W4320032904 cites W131564386 @default.
• W4320032904 cites W1514562415 @default.
• W4320032904 cites W1970609612 @default.
• W4320032904 cites W1971578941 @default.
• W4320032904 cites W1979733074 @default.
• W4320032904 cites W1981030303 @default.
• W4320032904 cites W1981515291 @default.
• W4320032904 cites W2012680472 @default.
• W4320032904 cites W2014677321 @default.
• W4320032904 cites W2022670940 @default.
• W4320032904 cites W2057228860 @default.
• W4320032904 cites W2060484997 @default.
• W4320032904 cites W2072998110 @default.
• W4320032904 cites W2110547872 @default.
• W4320032904 cites W2121679131 @default.
• W4320032904 cites W2125505694 @default.
• W4320032904 cites W2131549592 @default.
• W4320032904 cites W2139935404 @default.
• W4320032904 cites W2154589460 @default.
• W4320032904 cites W2155826575 @default.
• W4320032904 cites W2158438223 @default.
• W4320032904 cites W2169488737 @default.
• W4320032904 cites W2171808845 @default.
• W4320032904 cites W2290985779 @default.
• W4320032904 cites W2338391827 @default.
• W4320032904 cites W2543492720 @default.
• W4320032904 cites W2560824455 @default.
• W4320032904 cites W2572258568 @default.
• W4320032904 cites W2600313174 @default.
• W4320032904 cites W2600787581 @default.
• W4320032904 cites W2727509207 @default.
• W4320032904 cites W2791887519 @default.
• W4320032904 cites W2802479546 @default.
• W4320032904 cites W2889202763 @default.
• W4320032904 cites W2898514276 @default.
• W4320032904 cites W2950758110 @default.
• W4320032904 cites W2955544205 @default.
• W4320032904 cites W2958184371 @default.
• W4320032904 cites W2960524728 @default.
• W4320032904 cites W2969590269 @default.
• W4320032904 cites W3020686985 @default.
• W4320032904 cites W3038632482 @default.
• W4320032904 cites W3044825838 @default.
• W4320032904 cites W3104247842 @default.
• W4320032904 cites W3133757693 @default.
• W4320032904 cites W3173122333 @default.
• W4320032904 cites W3184658440 @default.
• W4320032904 cites W4200192266 @default.
• W4320032904 cites W4231356616 @default.
• W4320032904 cites W4291777060 @default.
• W4320032904 doi "https://doi.org/10.1093/nar/gkad077" @default.
• W4320032904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36772828" @default.
• W4320032904 hasPublicationYear "2023" @default.
• W4320032904 type Work @default.
• W4320032904 citedByCount "1" @default.
• W4320032904 countsByYear W43200329042023 @default.
• W4320032904 crossrefType "journal-article" @default.
• W4320032904 hasAuthorship W4320032904A5013617011 @default.
• W4320032904 hasAuthorship W4320032904A5048097785 @default.
• W4320032904 hasAuthorship W4320032904A5056656832 @default.
• W4320032904 hasAuthorship W4320032904A5058325475 @default.
• W4320032904 hasBestOaLocation W43200329041 @default.
• W4320032904 hasConcept C101762097 @default.
• W4320032904 hasConcept C104317684 @default.
• W4320032904 hasConcept C138885662 @default.
• W4320032904 hasConcept C150194340 @default.
• W4320032904 hasConcept C179926584 @default.
• W4320032904 hasConcept C41895202 @default.
• W4320032904 hasConcept C54355233 @default.
• W4320032904 hasConcept C83640560 @default.
• W4320032904 hasConcept C86339819 @default.
• W4320032904 hasConcept C86803240 @default.
• W4320032904 hasConcept C95444343 @default.
• W4320032904 hasConceptScore W4320032904C101762097 @default.
• W4320032904 hasConceptScore W4320032904C104317684 @default.
• W4320032904 hasConceptScore W4320032904C138885662 @default.
• W4320032904 hasConceptScore W4320032904C150194340 @default.
• W4320032904 hasConceptScore W4320032904C179926584 @default.
• W4320032904 hasConceptScore W4320032904C41895202 @default.
• W4320032904 hasConceptScore W4320032904C54355233 @default.
• W4320032904 hasConceptScore W4320032904C83640560 @default.
• W4320032904 hasConceptScore W4320032904C86339819 @default.
• W4320032904 hasConceptScore W4320032904C86803240 @default.
• W4320032904 hasConceptScore W4320032904C95444343 @default.
• W4320032904 hasFunder F4320332161 @default.
• W4320032904 hasFunder F4320337472 @default.
• W4320032904 hasIssue "8" @default.
• W4320032904 hasLocation W43200329041 @default.
• W4320032904 hasLocation W43200329042 @default.

• next