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• W4320032914 abstract "Nucleosomes, containing histone variants H2A.Z, are important for gene transcription initiation and termination, chromosome segregation and DNA double-strand break repair, among other functions. However, the underlying mechanisms of how H2A.Z influences nucleosome stability, dynamics and DNA accessibility are not well understood, as experimental and computational evidence remains inconclusive. Our modeling efforts of human nucleosome stability and dynamics, along with comparisons with experimental data show that the incorporation of H2A.Z results in a substantial decrease of the energy barrier for DNA unwrapping. This leads to the spontaneous DNA unwrapping of about forty base pairs from both ends, nucleosome gapping and increased histone plasticity, which otherwise is not observed for canonical nucleosomes. We demonstrate that both N- and C-terminal tails of H2A.Z play major roles in these events, whereas the H3.3 variant exerts a negligible impact in modulating the DNA end unwrapping. In summary, our results indicate that H2A.Z deposition makes nucleosomes more mobile and DNA more accessible to transcriptional machinery and other chromatin components." @default.
• W4320032914 created "2023-02-12" @default.
• W4320032914 creator A5044245258 @default.
• W4320032914 creator A5055860373 @default.
• W4320032914 creator A5080893873 @default.
• W4320032914 date "2023-02-11" @default.
• W4320032914 modified "2023-10-16" @default.
• W4320032914 title "Histone variant H2A.Z modulates nucleosome dynamics to promote DNA accessibility" @default.
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• W4320032914 doi "https://doi.org/10.1038/s41467-023-36465-5" @default.
• W4320032914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36765119" @default.
• W4320032914 hasPublicationYear "2023" @default.
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• W4320032914 hasAuthorship W4320032914A5044245258 @default.

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