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- W4320034413 abstract "The development of seven-membered heterocyclic scaffolds, namely benzothiazepine, has gained much recognition in mild environmentally friendly conditions such as low temperature and short reaction time due to its vast medicinal pertinence. A novel class of [1,5]-benzothiazepine-C-β-D-glycosides was synthesized in a facile one-pot method from α, β-unsaturated-b-C-glycosidic ketones where the use of p-TSA had shown a better result. The β-anomeric forms of the C-glycosidic compounds were assigned from 1H NMR spectroscopy. Studies propose that the series of [1,5]-benzothiazepine-based β-C-glycosides showed moderate anti-oxidant activities with maximum inhibitory activity of 60%. The second generation [1,5]-benzothiazepine-β-C-glycoside (piperonal derivative) with 1,3-benzodioxole-substitution (compound 10d) especially showed excellent anti-oxidant characteristics at all concentrations ranging from 100 to 600 μg/mL." @default.
- W4320034413 created "2023-02-12" @default.
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- W4320034413 date "2023-06-01" @default.
- W4320034413 modified "2023-09-29" @default.
- W4320034413 title "Synthesis of a novel series of [1,5]-benzothiazepine-C-β-D-glycoside derivatives in a facile one-pot method and insight into their anti-oxidant properties" @default.
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