Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320034429> ?p ?o ?g. }
- W4320034429 abstract "Glioblastoma, the most common and aggressive primary brain tumor type, is considered an immunologically cold tumor with sparse infiltration by adaptive immune cells. Immunosuppressive tumor-associated myeloid cells are drivers of tumor progression. Therefore, targeting and reprogramming intratumoral myeloid cells is an appealing therapeutic strategy. Here, we investigate a β-cyclodextrin nanoparticle (CDNP) formulation encapsulating the Toll-like receptor 7 and 8 (TLR7/8) agonist R848 (CDNP-R848) to reprogram myeloid cells in the glioma microenvironment. We show that intravenous monotherapy with CDNP-R848 induces regression of established syngeneic experimental glioma, resulting in increased survival rates compared with unloaded CDNP controls. Mechanistically, CDNP-R848 treatment reshapes the immunosuppressive tumor microenvironment and orchestrates tumor clearing by pro-inflammatory tumor-associated myeloid cells, independently of T cells and NK cells. Using serial magnetic resonance imaging, we identify a radiomic signature in response to CDNP-R848 treatment and ultrasmall superparamagnetic iron oxide (USPIO) imaging reveals that immunosuppressive macrophage recruitment is reduced by CDNP-R848. In conclusion, CDNP-R848 induces tumor regression in experimental glioma by targeting blood-borne macrophages without requiring adaptive immunity." @default.
- W4320034429 created "2023-02-12" @default.
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- W4320034429 date "2023-02-11" @default.
- W4320034429 modified "2023-10-15" @default.
- W4320034429 title "T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles" @default.
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- W4320034429 doi "https://doi.org/10.1038/s41467-023-36321-6" @default.
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- W4320034429 hasPublicationYear "2023" @default.
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