Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320034493> ?p ?o ?g. }
- W4320034493 endingPage "175584" @default.
- W4320034493 startingPage "175584" @default.
- W4320034493 abstract "Apigenin is a natural flavonoid which is widely found in vegetables and fruits. However, the mechanism of apigenin in oxidative stress-induced myocardial injury has not been fully elucidated. We established an isoproterenol (Iso)-induced myocardial injury mouse model and a hypoxia/reoxygenation (H/R)-induced H9c2 cell injury model, followed by pretreatment with apigenin to explore its protective effects. Apigenin can significantly alleviate isoproterenol-induced oxidative stress, cell apoptosis and myocardial remodeling in vivo. Apigenin pretreatment can also significantly improve cardiomyocyte morphology, decrease H/R induced oxidative stress, and attenuate cell apoptosis and inflammation in vitro. Further mechanism study revealed that apigenin treatment reversed isoprenaline and H/R-induced decrease of Sirtuin1 (SIRT1). Molecular docking results proved that apigenin can form hydrogen bond with 230 Glu, a key site of SIRT1 activation, indicating that apigenin is an agonist of SIRT1. Moreover, SIRT1 knockdown by siRNA significantly reversed the protective effect of apigenin in H/R-induced myocardial injury. In conclusion, apigenin protects cardiomyocyte function from oxidative stress-induced myocardial injury by modulating SIRT1 signaling pathway, which provides a new potential therapeutic natural compound for the clinical treatment of cardiovascular diseases." @default.
- W4320034493 created "2023-02-12" @default.
- W4320034493 creator A5001363727 @default.
- W4320034493 creator A5003049767 @default.
- W4320034493 creator A5005877937 @default.
- W4320034493 creator A5014528965 @default.
- W4320034493 creator A5019551624 @default.
- W4320034493 creator A5020133148 @default.
- W4320034493 creator A5026213838 @default.
- W4320034493 creator A5038462987 @default.
- W4320034493 creator A5052883326 @default.
- W4320034493 creator A5053725057 @default.
- W4320034493 creator A5057912307 @default.
- W4320034493 creator A5060479110 @default.
- W4320034493 creator A5060557882 @default.
- W4320034493 creator A5064496142 @default.
- W4320034493 creator A5066061403 @default.
- W4320034493 creator A5066141913 @default.
- W4320034493 creator A5079282768 @default.
- W4320034493 creator A5089782564 @default.
- W4320034493 date "2023-04-01" @default.
- W4320034493 modified "2023-10-17" @default.
- W4320034493 title "Apigenin alleviates oxidative stress-induced myocardial injury by regulating SIRT1 signaling pathway" @default.
- W4320034493 cites W1565431211 @default.
- W4320034493 cites W1979657807 @default.
- W4320034493 cites W1999549953 @default.
- W4320034493 cites W2043723940 @default.
- W4320034493 cites W2061227824 @default.
- W4320034493 cites W2414014515 @default.
- W4320034493 cites W2560693443 @default.
- W4320034493 cites W2569062792 @default.
- W4320034493 cites W2605122807 @default.
- W4320034493 cites W2754665187 @default.
- W4320034493 cites W2765596630 @default.
- W4320034493 cites W2788071548 @default.
- W4320034493 cites W2790342927 @default.
- W4320034493 cites W2794554845 @default.
- W4320034493 cites W2891614594 @default.
- W4320034493 cites W2910312197 @default.
- W4320034493 cites W2913506254 @default.
- W4320034493 cites W2943266675 @default.
- W4320034493 cites W2951345394 @default.
- W4320034493 cites W2965605043 @default.
- W4320034493 cites W2971456522 @default.
- W4320034493 cites W3007492121 @default.
- W4320034493 cites W3009744280 @default.
- W4320034493 cites W3045078804 @default.
- W4320034493 cites W3048916628 @default.
- W4320034493 cites W3080701870 @default.
- W4320034493 cites W3088080395 @default.
- W4320034493 cites W3109097500 @default.
- W4320034493 cites W3125766101 @default.
- W4320034493 cites W3133875511 @default.
- W4320034493 cites W3164768859 @default.
- W4320034493 cites W3165069054 @default.
- W4320034493 cites W3170083484 @default.
- W4320034493 cites W4200522462 @default.
- W4320034493 cites W4211173876 @default.
- W4320034493 cites W4223439450 @default.
- W4320034493 cites W4248078302 @default.
- W4320034493 cites W4311744984 @default.
- W4320034493 doi "https://doi.org/10.1016/j.ejphar.2023.175584" @default.
- W4320034493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36781043" @default.
- W4320034493 hasPublicationYear "2023" @default.
- W4320034493 type Work @default.
- W4320034493 citedByCount "1" @default.
- W4320034493 countsByYear W43200344932023 @default.
- W4320034493 crossrefType "journal-article" @default.
- W4320034493 hasAuthorship W4320034493A5001363727 @default.
- W4320034493 hasAuthorship W4320034493A5003049767 @default.
- W4320034493 hasAuthorship W4320034493A5005877937 @default.
- W4320034493 hasAuthorship W4320034493A5014528965 @default.
- W4320034493 hasAuthorship W4320034493A5019551624 @default.
- W4320034493 hasAuthorship W4320034493A5020133148 @default.
- W4320034493 hasAuthorship W4320034493A5026213838 @default.
- W4320034493 hasAuthorship W4320034493A5038462987 @default.
- W4320034493 hasAuthorship W4320034493A5052883326 @default.
- W4320034493 hasAuthorship W4320034493A5053725057 @default.
- W4320034493 hasAuthorship W4320034493A5057912307 @default.
- W4320034493 hasAuthorship W4320034493A5060479110 @default.
- W4320034493 hasAuthorship W4320034493A5060557882 @default.
- W4320034493 hasAuthorship W4320034493A5064496142 @default.
- W4320034493 hasAuthorship W4320034493A5066061403 @default.
- W4320034493 hasAuthorship W4320034493A5066141913 @default.
- W4320034493 hasAuthorship W4320034493A5079282768 @default.
- W4320034493 hasAuthorship W4320034493A5089782564 @default.
- W4320034493 hasConcept C126322002 @default.
- W4320034493 hasConcept C185592680 @default.
- W4320034493 hasConcept C190283241 @default.
- W4320034493 hasConcept C24998067 @default.
- W4320034493 hasConcept C2776090920 @default.
- W4320034493 hasConcept C2776151105 @default.
- W4320034493 hasConcept C2776914184 @default.
- W4320034493 hasConcept C2778004101 @default.
- W4320034493 hasConcept C2778609962 @default.
- W4320034493 hasConcept C2779054382 @default.
- W4320034493 hasConcept C48349386 @default.
- W4320034493 hasConcept C55493867 @default.