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- W4320036481 abstract "Many cases of aseptic meningitis or meningoencephalitis, unresponsive to antimicrobial treatments, have been reported recently in patients with established/new-onset central nervous system (CNS) inflammatory demyelinating diseases (CNSIDDs). Given the higher probability of infectious etiologies, CNSIDDs are rarely considered among the differentials in meningitis or meningoencephalitis cases. We gathered and tabulated cases of non-infectious, steroid-responsive meningitis or meningoencephalitis associated with neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein-associated disease (MOGAD). This conceptual review highlights the need to bolster routine infectious workups with immunological workups in cases of meningoencephalitis or meningitis where potential autoimmune etiologies can be suspected. Although differentiating CNSIDDs with meningeal involvement from infectious meningitis may not substantially affect acute treatment strategies, long-term management and follow-up of the two are entirely different. We also discuss future research directions and hypotheses on how CNSIDDs may be associated with meningitis-like presentations, e.g. overlapping glial fibrillary acidic protein astrocytopathy or autoimmune encephalitis, alterations in regulatory T-helper cells function, and undetected viral agents." @default.
- W4320036481 created "2023-02-12" @default.
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- W4320036481 date "2023-06-01" @default.
- W4320036481 modified "2023-10-16" @default.
- W4320036481 title "Non-infectious meningitis and CNS demyelinating diseases: A conceptual review" @default.
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- W4320036481 doi "https://doi.org/10.1016/j.neurol.2022.10.006" @default.
- W4320036481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36781321" @default.
- W4320036481 hasPublicationYear "2023" @default.
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