Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320038644> ?p ?o ?g. }
- W4320038644 abstract "Abstract The cellular lipidome is comprised of thousands of unique lipid species. This complexity underpins the many roles of lipids in cellular biology. How lipidome composition varies between cell types and how such differences contribute to cell-specific functionality is poorly understood. Here, using mass spectrometry-based targeted lipidomics, we have characterised the cellular lipid landscape of the human and mouse immune systems ( www.cellularlipidatlas.com ). We find that myeloid and lymphoid cell lineages have unique lipid compositions, notably in the usage of ester and ether bonds within glycerophospholipids (PLs) and PL acyl chain composition. To determine if immune cell-specific lipid phenotypes promote cell-specific functional properties we focused on differences in poly-unsaturated fatty acid (PUFA)-containing PL, the levels of which are markedly higher in lymphoid cells relative to myeloid cells. We firstly show that differences in PUFA-PL content provides a mechanistic basis for previously described differences in immune cell susceptibility to ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, and secondly, that the low PUFA-PL content of neutrophils restrains NADPH oxidase-driven ferroptosis. In summary, we show that the lipid landscape is a defining feature of immune cell identity and that cell-specific lipid phenotypes underpin aspects of immune cell physiology." @default.
- W4320038644 created "2023-02-12" @default.
- W4320038644 creator A5006247964 @default.
- W4320038644 creator A5018043741 @default.
- W4320038644 creator A5036079859 @default.
- W4320038644 creator A5043978940 @default.
- W4320038644 creator A5046060573 @default.
- W4320038644 creator A5053581328 @default.
- W4320038644 creator A5068012232 @default.
- W4320038644 creator A5072152104 @default.
- W4320038644 creator A5075712626 @default.
- W4320038644 creator A5079876374 @default.
- W4320038644 creator A5080053839 @default.
- W4320038644 creator A5082333879 @default.
- W4320038644 creator A5084156499 @default.
- W4320038644 creator A5090617104 @default.
- W4320038644 date "2023-02-10" @default.
- W4320038644 modified "2023-09-27" @default.
- W4320038644 title "An immune cell lipid atlas reveals the basis of susceptibility to ferroptosis" @default.
- W4320038644 cites W1529422432 @default.
- W4320038644 cites W1570340380 @default.
- W4320038644 cites W1965373646 @default.
- W4320038644 cites W1977216019 @default.
- W4320038644 cites W1988406374 @default.
- W4320038644 cites W1990402256 @default.
- W4320038644 cites W1997183854 @default.
- W4320038644 cites W2002285169 @default.
- W4320038644 cites W2002490399 @default.
- W4320038644 cites W2017347575 @default.
- W4320038644 cites W2029958712 @default.
- W4320038644 cites W2045950965 @default.
- W4320038644 cites W2060035882 @default.
- W4320038644 cites W2065934830 @default.
- W4320038644 cites W2068749469 @default.
- W4320038644 cites W2070607918 @default.
- W4320038644 cites W2072735872 @default.
- W4320038644 cites W2116687544 @default.
- W4320038644 cites W2127031535 @default.
- W4320038644 cites W2170417182 @default.
- W4320038644 cites W2337235326 @default.
- W4320038644 cites W2550324626 @default.
- W4320038644 cites W2599649240 @default.
- W4320038644 cites W2614874662 @default.
- W4320038644 cites W2747004888 @default.
- W4320038644 cites W2768617092 @default.
- W4320038644 cites W2772274254 @default.
- W4320038644 cites W2790705492 @default.
- W4320038644 cites W2792543387 @default.
- W4320038644 cites W2806826548 @default.
- W4320038644 cites W2899711354 @default.
- W4320038644 cites W2914524806 @default.
- W4320038644 cites W2936783190 @default.
- W4320038644 cites W2944723276 @default.
- W4320038644 cites W2945926178 @default.
- W4320038644 cites W2980472864 @default.
- W4320038644 cites W2981179816 @default.
- W4320038644 cites W2995931534 @default.
- W4320038644 cites W3006247487 @default.
- W4320038644 cites W3023999421 @default.
- W4320038644 cites W3034538110 @default.
- W4320038644 cites W3048885175 @default.
- W4320038644 cites W3072295979 @default.
- W4320038644 cites W3087176574 @default.
- W4320038644 cites W3109639956 @default.
- W4320038644 cites W3123922203 @default.
- W4320038644 cites W3134959125 @default.
- W4320038644 cites W3160741177 @default.
- W4320038644 cites W3162306949 @default.
- W4320038644 cites W3167697154 @default.
- W4320038644 cites W3169102532 @default.
- W4320038644 cites W3193346373 @default.
- W4320038644 cites W3204688027 @default.
- W4320038644 cites W4206320827 @default.
- W4320038644 doi "https://doi.org/10.1101/2023.02.10.528075" @default.
- W4320038644 hasPublicationYear "2023" @default.
- W4320038644 type Work @default.
- W4320038644 citedByCount "0" @default.
- W4320038644 crossrefType "posted-content" @default.
- W4320038644 hasAuthorship W4320038644A5006247964 @default.
- W4320038644 hasAuthorship W4320038644A5018043741 @default.
- W4320038644 hasAuthorship W4320038644A5036079859 @default.
- W4320038644 hasAuthorship W4320038644A5043978940 @default.
- W4320038644 hasAuthorship W4320038644A5046060573 @default.
- W4320038644 hasAuthorship W4320038644A5053581328 @default.
- W4320038644 hasAuthorship W4320038644A5068012232 @default.
- W4320038644 hasAuthorship W4320038644A5072152104 @default.
- W4320038644 hasAuthorship W4320038644A5075712626 @default.
- W4320038644 hasAuthorship W4320038644A5079876374 @default.
- W4320038644 hasAuthorship W4320038644A5080053839 @default.
- W4320038644 hasAuthorship W4320038644A5082333879 @default.
- W4320038644 hasAuthorship W4320038644A5084156499 @default.
- W4320038644 hasAuthorship W4320038644A5090617104 @default.
- W4320038644 hasBestOaLocation W43200386441 @default.
- W4320038644 hasConcept C1491633281 @default.
- W4320038644 hasConcept C185592680 @default.
- W4320038644 hasConcept C189014844 @default.
- W4320038644 hasConcept C203014093 @default.
- W4320038644 hasConcept C2778918659 @default.
- W4320038644 hasConcept C2780241833 @default.
- W4320038644 hasConcept C2909522894 @default.