Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320038961> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4320038961 abstract "Abstract Background Genomic testing has enhanced pre-surgical decision making for cytologically indeterminate thyroid nodules, but there remains uncertainty regarding RAS mutations. The addition of extra genetic alterations to previous driver mutation panels has been shown to improve predictive value. This study aims to evaluate the relationship between the mutant allele frequency (AF) and likelihood of malignancy in thyroid nodules with RAS mutations. Methods A retrospective cohort review was performed evaluating patients with indeterminate cytology (Bethesda categories III, IV and V) and ThyroSeq® v3 testing demonstrating a RAS mutation, who underwent surgery. Univariate and multivariate regression analyses were used to evaluate relationships between AF, other genetic alterations, and malignancy. Results Thirty-nine patients met criteria, 77% of the thyroid nodules (30/39) were found to be malignant. None demonstrated aggressive pathology. On univariate regression, there was no relationship between AF and likelihood of malignancy. There was, however, a significant correlation between AF and the rate of an additional genetic alteration. Multivariate analysis found a trend between RAS , a second genetic alteration and malignancy, but it did not reach statistical significance. Conclusions There was no direct relationship between the level of allelic frequency in thyroid nodules expressing RAS mutations and the likelihood of malignancy. There was a statistically significant relationship between increasing AF and the presence of a second genetic abnormality, suggesting a possible progression from initial driver mutation and then a second genetic alteration prior to malignant transformation. Graphical abstract" @default.
- W4320038961 created "2023-02-12" @default.
- W4320038961 creator A5020025409 @default.
- W4320038961 creator A5027968344 @default.
- W4320038961 creator A5036396125 @default.
- W4320038961 creator A5038199525 @default.
- W4320038961 creator A5047948502 @default.
- W4320038961 creator A5060105528 @default.
- W4320038961 date "2023-02-11" @default.
- W4320038961 modified "2023-10-15" @default.
- W4320038961 title "Does the likelihood of malignancy in thyroid nodules with RAS mutations increase in direct proportion with the allele frequency percentage?" @default.
- W4320038961 cites W1961136802 @default.
- W4320038961 cites W2005890649 @default.
- W4320038961 cites W2030695368 @default.
- W4320038961 cites W2045687592 @default.
- W4320038961 cites W2053286013 @default.
- W4320038961 cites W2071333584 @default.
- W4320038961 cites W2083695927 @default.
- W4320038961 cites W2093010205 @default.
- W4320038961 cites W2110540659 @default.
- W4320038961 cites W2115930691 @default.
- W4320038961 cites W2145150141 @default.
- W4320038961 cites W2159594827 @default.
- W4320038961 cites W2168261275 @default.
- W4320038961 cites W2168388892 @default.
- W4320038961 cites W2235523093 @default.
- W4320038961 cites W2553638316 @default.
- W4320038961 cites W2582368326 @default.
- W4320038961 cites W2766712571 @default.
- W4320038961 cites W2792088630 @default.
- W4320038961 cites W2804198114 @default.
- W4320038961 cites W2889646458 @default.
- W4320038961 cites W2900078105 @default.
- W4320038961 cites W2915242132 @default.
- W4320038961 cites W3003825098 @default.
- W4320038961 cites W3048164757 @default.
- W4320038961 cites W3134170563 @default.
- W4320038961 cites W3186405496 @default.
- W4320038961 cites W3206477047 @default.
- W4320038961 doi "https://doi.org/10.1186/s40463-022-00611-8" @default.
- W4320038961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36774522" @default.
- W4320038961 hasPublicationYear "2023" @default.
- W4320038961 type Work @default.
- W4320038961 citedByCount "0" @default.
- W4320038961 crossrefType "journal-article" @default.
- W4320038961 hasAuthorship W4320038961A5020025409 @default.
- W4320038961 hasAuthorship W4320038961A5027968344 @default.
- W4320038961 hasAuthorship W4320038961A5036396125 @default.
- W4320038961 hasAuthorship W4320038961A5038199525 @default.
- W4320038961 hasAuthorship W4320038961A5047948502 @default.
- W4320038961 hasAuthorship W4320038961A5060105528 @default.
- W4320038961 hasBestOaLocation W43200389611 @default.
- W4320038961 hasConcept C126322002 @default.
- W4320038961 hasConcept C142724271 @default.
- W4320038961 hasConcept C143998085 @default.
- W4320038961 hasConcept C144301174 @default.
- W4320038961 hasConcept C2779022025 @default.
- W4320038961 hasConcept C2779399171 @default.
- W4320038961 hasConcept C38180746 @default.
- W4320038961 hasConcept C71924100 @default.
- W4320038961 hasConcept C86803240 @default.
- W4320038961 hasConceptScore W4320038961C126322002 @default.
- W4320038961 hasConceptScore W4320038961C142724271 @default.
- W4320038961 hasConceptScore W4320038961C143998085 @default.
- W4320038961 hasConceptScore W4320038961C144301174 @default.
- W4320038961 hasConceptScore W4320038961C2779022025 @default.
- W4320038961 hasConceptScore W4320038961C2779399171 @default.
- W4320038961 hasConceptScore W4320038961C38180746 @default.
- W4320038961 hasConceptScore W4320038961C71924100 @default.
- W4320038961 hasConceptScore W4320038961C86803240 @default.
- W4320038961 hasIssue "1" @default.
- W4320038961 hasLocation W43200389611 @default.
- W4320038961 hasLocation W43200389612 @default.
- W4320038961 hasLocation W43200389613 @default.
- W4320038961 hasOpenAccess W4320038961 @default.
- W4320038961 hasPrimaryLocation W43200389611 @default.
- W4320038961 hasRelatedWork W195067670 @default.
- W4320038961 hasRelatedWork W2002418205 @default.
- W4320038961 hasRelatedWork W2030729277 @default.
- W4320038961 hasRelatedWork W2034204715 @default.
- W4320038961 hasRelatedWork W2107781977 @default.
- W4320038961 hasRelatedWork W2361700749 @default.
- W4320038961 hasRelatedWork W2614970116 @default.
- W4320038961 hasRelatedWork W2887214816 @default.
- W4320038961 hasRelatedWork W2970752085 @default.
- W4320038961 hasRelatedWork W3150878934 @default.
- W4320038961 hasVolume "52" @default.
- W4320038961 isParatext "false" @default.
- W4320038961 isRetracted "false" @default.
- W4320038961 workType "article" @default.