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• W4320040180 abstract "Pituitary neuroendocrine tumours (PitNETs) are neoplasms of the pituitary that overproduce hormones or cause unspecific symptoms due to mass effect. Growth hormone overproducing GH-producing PitNETs cause acromegaly leading to connective tissue, metabolic or oncologic disorders. The medical treatment of acromegaly is somatostatin analogues (SSA) in specific cases combined with dopamine agonists (DA), but almost half of patients display partial or full SSA resistance and potential causes of this are unknown. In this study we investigated transcriptomic landscape of GH-producing PitNETs on several levels and functional models-tumour tissue of patients with and without SSA preoperative treatment, tumour derived pituispheres and GH3 cell line incubated with SSA to study effect of medication on gene expression. MGI sequencing platform was used to sequence total RNA from PitNET tissue, pituispheres, mesenchymal stromal stem-like cells (MSC), and GH3 cell cultures, and data were analysed with Salmon-DeSeq2 pipeline. We observed that the GH-producing PitNETs have distinct changes in growth hormone related pathways related to its functional status alongside inner cell signalling, ion transport, cell adhesion and extracellular matrix characteristic patterns. In pituispheres model, treatment regimens (octreotide and cabergoline) affect specific cell proliferation (MKI67) and core functionality pathways (RYR2, COL8A2, HLA-G, ARFGAP1, TGFBR2). In GH3 cells we observed that medication did not have transcriptomic effects similar to preoperative treatment in PitNET tissue or pituisphere model. This study highlights the importance of correct model system selection for cell transcriptomic profiling and data interpretation that could be achieved in future by incorporating NGS methods and detailed cell omics profiling in PitNET model research." @default.
• W4320040180 created "2023-02-12" @default.
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• W4320040180 date "2023-02-11" @default.
• W4320040180 modified "2023-09-26" @default.
• W4320040180 title "Transcriptome of GH-producing pituitary neuroendocrine tumours and models are significantly affected by somatostatin analogues" @default.
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• W4320040180 cites W1982758905 @default.
• W4320040180 cites W1990307054 @default.
• W4320040180 cites W2025600112 @default.
• W4320040180 cites W2040691343 @default.
• W4320040180 cites W2045691764 @default.
• W4320040180 cites W2046498578 @default.
• W4320040180 cites W2058890667 @default.
• W4320040180 cites W2062372161 @default.
• W4320040180 cites W2067318470 @default.
• W4320040180 cites W2068749976 @default.
• W4320040180 cites W2081324142 @default.
• W4320040180 cites W2091826524 @default.
• W4320040180 cites W2096192437 @default.
• W4320040180 cites W2116635624 @default.
• W4320040180 cites W2124799197 @default.
• W4320040180 cites W2128652740 @default.
• W4320040180 cites W2140311750 @default.
• W4320040180 cites W2142623709 @default.
• W4320040180 cites W2148634043 @default.
• W4320040180 cites W2166330620 @default.
• W4320040180 cites W2171537806 @default.
• W4320040180 cites W2179438025 @default.
• W4320040180 cites W2192349934 @default.
• W4320040180 cites W2208793511 @default.
• W4320040180 cites W2245508602 @default.
• W4320040180 cites W2345002956 @default.
• W4320040180 cites W2418024629 @default.
• W4320040180 cites W2432815617 @default.
• W4320040180 cites W2479442657 @default.
• W4320040180 cites W2525902479 @default.
• W4320040180 cites W2535531496 @default.
• W4320040180 cites W2586116929 @default.
• W4320040180 cites W2592811885 @default.
• W4320040180 cites W2601247544 @default.
• W4320040180 cites W2603415840 @default.
• W4320040180 cites W2757254843 @default.
• W4320040180 cites W2770145603 @default.
• W4320040180 cites W2772005463 @default.
• W4320040180 cites W2773582723 @default.
• W4320040180 cites W2778869406 @default.
• W4320040180 cites W2784126175 @default.
• W4320040180 cites W2790996238 @default.
• W4320040180 cites W2884078888 @default.
• W4320040180 cites W2884153996 @default.
• W4320040180 cites W2907350327 @default.
• W4320040180 cites W2910326417 @default.
• W4320040180 cites W2922087323 @default.
• W4320040180 cites W2951912016 @default.
• W4320040180 cites W2976602440 @default.
• W4320040180 cites W2981291815 @default.
• W4320040180 cites W2987630632 @default.
• W4320040180 cites W2990063843 @default.
• W4320040180 cites W2990955281 @default.
• W4320040180 cites W2996928569 @default.
• W4320040180 cites W3005279764 @default.
• W4320040180 cites W3006874692 @default.
• W4320040180 cites W3007273059 @default.
• W4320040180 cites W3027836699 @default.
• W4320040180 cites W3038086130 @default.
• W4320040180 cites W3043256601 @default.
• W4320040180 cites W3045994199 @default.
• W4320040180 cites W3100396702 @default.
• W4320040180 cites W3107527779 @default.
• W4320040180 cites W3117715483 @default.
• W4320040180 cites W3126208431 @default.
• W4320040180 cites W3128755494 @default.
• W4320040180 cites W3131584332 @default.
• W4320040180 cites W3135845639 @default.
• W4320040180 cites W3138349504 @default.
• W4320040180 cites W3166812652 @default.
• W4320040180 cites W3174609537 @default.
• W4320040180 cites W3183722853 @default.
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• W4320040180 cites W4254687493 @default.
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• W4320040180 doi "https://doi.org/10.1186/s12935-023-02863-4" @default.
• W4320040180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36774501" @default.
• W4320040180 hasPublicationYear "2023" @default.

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