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• W4320040833 abstract "Due to the difficulty in accurately identifying structural variants (SVs) across genomes, their impact on <i>cis</i>-regulatory divergence of closely related species, especially fish, remains to be explored. Recently identified broad H3K4me3 domains are essential for the regulation of genes involved in several biological processes. However, the role of broad H3K4me3 domains in phenotypic divergence remains poorly understood. <i>Siniperca chuatsi</i> and <i>S. scherzeri</i> are closely related but divergent in several phenotypic traits, making them an ideal model to study <i>cis</i>-regulatory evolution in sister species. Here, we generated chromosome-level genomes of <i>S. chuatsi</i> and <i>S. scherzeri</i>, with assembled genome sizes of 716.35 and 740.54 Mb, respectively. The evolutionary histories of <i>S. chuatsi</i> and <i>S. scherzeri</i> were studied by inferring dynamic changes in ancestral population sizes. To explore the genetic basis of adaptation in <i>S. chuatsi</i> and <i>S. scherzeri</i>, we performed gene family expansion and contraction analysis and identified positively selected genes (PSGs). To investigate the role of SVs in <i>cis</i>-regulatory divergence of closely related fish species, we identified high-quality SVs as well as divergent H3K27ac and H3K4me3 domains in the genomes of <i>S. chuatsi</i> and <i>S. scherzeri</i>. Integrated analysis revealed that <i>cis</i>-regulatory divergence caused by SVs played an essential role in phenotypic divergence between <i>S. chuatsi</i> and <i>S. scherzeri</i>. Additionally, divergent broad H3K4me3 domains were mostly associated with cancer-related genes in <i>S. chuatsi</i> and <i>S. scherzeri</i> and contributed to their phenotypic divergence." @default.
• W4320040833 created "2023-02-12" @default.
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• W4320040833 date "2023-01-01" @default.
• W4320040833 modified "2023-09-26" @default.
• W4320040833 title "Long-read genome assemblies reveal a <i>cis</i>-regulatory landscape associated with phenotypic divergence in two sister <i>Siniperca</i> fish species" @default.
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