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- W4320061567 startingPage "98.17" @default.
- W4320061567 abstract "Abstract Regulatory T cells (Tregs) are suppressive T cells which help to control and dampen immune responses. Tregs naturally suppress potentially autoreactive T cells, and are used in a variety of T cell-mediated therapies. While these cells are very useful for controlling improper or overactive immune responses in disease, they are found in low frequencies in the body, and their exact mechanisms of action are still unknown. Tregs typically express CD4, CD25, and FOXP3, with FOXP3 being considered a defining lineage transcription factor. However, in some contexts, noncanonical Tregs that are CD4+ FOXP3+ CD25− have been described, and have been shown to be suppressive in some cases. It is still unclear which transcription factors play a role in regulating these noncanonical Tregs. We utilized a mouse strain with T-cell specific deletion of a critical transcription factor, T Cell Factor-1 (TCF-1) to determine the role of TCF-1 in controlling Tregs. We report that loss of TCF-1 specifically in T cells of mice results in cell-intrinsic expansion of CD25− Tregs. We also show that TCF-1-deficient T cells have a prion-like ability to influence Treg fate of nearby WT T cells. These CD25− Tregs are found in multiple peripheral tissues, express other functional Treg markers (CTLA-4 and IL-10), and are not the result of aberrant FOXP3 expression. Therefore, TCF-1 acts as a regulatory transcription factor for these CD25− Tregs. Modulation of TCF-1 may increase yield of noncanonical Tregs, providing benefit for T cell-mediated therapies and further study of noncanonical Tregs." @default.
- W4320061567 created "2023-02-12" @default.
- W4320061567 creator A5011145184 @default.
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- W4320061567 date "2021-05-01" @default.
- W4320061567 modified "2023-10-16" @default.
- W4320061567 title "TCF-1 deficiency produces prion-like expansion of noncanonical regulatory T cells" @default.
- W4320061567 doi "https://doi.org/10.4049/jimmunol.206.supp.98.17" @default.
- W4320061567 hasPublicationYear "2021" @default.
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