Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320065589> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4320065589 abstract "Background and Aim Wood smoke is a complex mixture of gases, chemicals, and fine particles generated by wood-burning and wildfires. We are conducting a cancer hazard evaluation of wood smoke for possible listing in the U.S. Report on Carcinogens. The database of cancer epidemiology studies for exposure to wood smoke, but not wildfire, is adequate to conduct an evaluation. As mechanistic evidence may inform the overall hazard evaluation, especially for wildfires, we mapped the published evidence by biomarkers for the key characteristic of carcinogens (KCC), focusing here on studies in exposed humans. Methods We systematically searched three bibliographic databases for relevant biomarker studies on wildfire and wood smoke exposure. For selected studies reporting on the three most common KCCs (genotoxicity, oxidative stress, immune biomarkers), we extracted information including specific KCC biomarkers (e.g., mutations), results, study design, and population, and presented the data in an interactive evidence map. Results Wood smoke: Most human studies (26) found positive associations with KCCs, consistent with the >70 non-human studies (in vitro and in vivo). Inflammation, inflammatory cytokines, and lipid peroxidation were the most common KCCs in humans. The studies were primarily intervention or cross-sectional in populations cooking or heating with wood or randomized studies of controlled exposure. Wildfires: Human studies (15) were largely positive for immune biomarkers but inconsistent for genotoxicity and oxidative stress, whereas non-human studies (17) were generally positive for all endpoints. Most studies measured KCCs in firefighters (13) before or after exposure (e.g., work shift or natural wildfire event). Conclusions Wildfires are increasing in frequency and intensity due to climate change, and exposure to wood smoke remains a worldwide concern. This mechanistic evidence will help inform the cancer hazard evaluations of these exposures. Ongoing risk-of-bias evaluations may explain heterogeneity in human wildfire studies. Keywords Wood smoke, wildfires, biomarkers, exposed humans" @default.
- W4320065589 created "2023-02-12" @default.
- W4320065589 creator A5000745956 @default.
- W4320065589 creator A5031820780 @default.
- W4320065589 creator A5033306704 @default.
- W4320065589 creator A5053255520 @default.
- W4320065589 creator A5055418047 @default.
- W4320065589 creator A5070576708 @default.
- W4320065589 date "2022-09-18" @default.
- W4320065589 modified "2023-10-16" @default.
- W4320065589 title "Mapping the mechanistic evidence of wood smoke and wildfire studies in humans" @default.
- W4320065589 doi "https://doi.org/10.1289/isee.2022.o-op-203" @default.
- W4320065589 hasPublicationYear "2022" @default.
- W4320065589 type Work @default.
- W4320065589 citedByCount "0" @default.
- W4320065589 crossrefType "journal-article" @default.
- W4320065589 hasAuthorship W4320065589A5000745956 @default.
- W4320065589 hasAuthorship W4320065589A5031820780 @default.
- W4320065589 hasAuthorship W4320065589A5033306704 @default.
- W4320065589 hasAuthorship W4320065589A5053255520 @default.
- W4320065589 hasAuthorship W4320065589A5055418047 @default.
- W4320065589 hasAuthorship W4320065589A5070576708 @default.
- W4320065589 hasConcept C114246631 @default.
- W4320065589 hasConcept C126322002 @default.
- W4320065589 hasConcept C178790620 @default.
- W4320065589 hasConcept C185592680 @default.
- W4320065589 hasConcept C198408306 @default.
- W4320065589 hasConcept C2778959862 @default.
- W4320065589 hasConcept C2781197716 @default.
- W4320065589 hasConcept C2908647359 @default.
- W4320065589 hasConcept C29730261 @default.
- W4320065589 hasConcept C33070731 @default.
- W4320065589 hasConcept C54355233 @default.
- W4320065589 hasConcept C58874564 @default.
- W4320065589 hasConcept C71924100 @default.
- W4320065589 hasConcept C86803240 @default.
- W4320065589 hasConcept C99454951 @default.
- W4320065589 hasConceptScore W4320065589C114246631 @default.
- W4320065589 hasConceptScore W4320065589C126322002 @default.
- W4320065589 hasConceptScore W4320065589C178790620 @default.
- W4320065589 hasConceptScore W4320065589C185592680 @default.
- W4320065589 hasConceptScore W4320065589C198408306 @default.
- W4320065589 hasConceptScore W4320065589C2778959862 @default.
- W4320065589 hasConceptScore W4320065589C2781197716 @default.
- W4320065589 hasConceptScore W4320065589C2908647359 @default.
- W4320065589 hasConceptScore W4320065589C29730261 @default.
- W4320065589 hasConceptScore W4320065589C33070731 @default.
- W4320065589 hasConceptScore W4320065589C54355233 @default.
- W4320065589 hasConceptScore W4320065589C58874564 @default.
- W4320065589 hasConceptScore W4320065589C71924100 @default.
- W4320065589 hasConceptScore W4320065589C86803240 @default.
- W4320065589 hasConceptScore W4320065589C99454951 @default.
- W4320065589 hasIssue "1" @default.
- W4320065589 hasLocation W43200655891 @default.
- W4320065589 hasOpenAccess W4320065589 @default.
- W4320065589 hasPrimaryLocation W43200655891 @default.
- W4320065589 hasRelatedWork W1549428515 @default.
- W4320065589 hasRelatedWork W1970521072 @default.
- W4320065589 hasRelatedWork W2012301514 @default.
- W4320065589 hasRelatedWork W2025315079 @default.
- W4320065589 hasRelatedWork W2030231118 @default.
- W4320065589 hasRelatedWork W2188721396 @default.
- W4320065589 hasRelatedWork W2805812827 @default.
- W4320065589 hasRelatedWork W2955366523 @default.
- W4320065589 hasRelatedWork W3047294372 @default.
- W4320065589 hasRelatedWork W3080368582 @default.
- W4320065589 hasVolume "2022" @default.
- W4320065589 isParatext "false" @default.
- W4320065589 isRetracted "false" @default.
- W4320065589 workType "article" @default.