Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320076656> ?p ?o ?g. }
- W4320076656 endingPage "413" @default.
- W4320076656 startingPage "413" @default.
- W4320076656 abstract "Venezuelan, western, and eastern equine encephalitic alphaviruses (VEEV, WEEV, and EEEV, respectively) are arboviruses that are highly pathogenic to equines and cause significant harm to infected humans. Currently, human alphavirus infection and the resulting diseases caused by them are unmitigated due to the absence of approved vaccines or therapeutics for general use. These circumstances, combined with the unpredictability of outbreaks-as exemplified by a 2019 EEE surge in the United States that claimed 19 patient lives-emphasize the risks posed by these viruses, especially for aerosolized VEEV and EEEV which are potential biothreats. Herein, small molecule inhibitors of VEEV, WEEV, and EEEV are reviewed that have been identified or advanced in the last five years since a comprehensive review was last performed. We organize structures according to host- versus virus-targeted mechanisms, highlight cellular and animal data that are milestones in the development pipeline, and provide a perspective on key considerations for the progression of compounds at early and later stages of advancement." @default.
- W4320076656 created "2023-02-12" @default.
- W4320076656 creator A5009122704 @default.
- W4320076656 creator A5070735083 @default.
- W4320076656 date "2023-02-01" @default.
- W4320076656 modified "2023-09-30" @default.
- W4320076656 title "Advances in the Development of Small Molecule Antivirals against Equine Encephalitic Viruses" @default.
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