FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320155972> ?p ?o ?g. }

• W4320155972 endingPage "20" @default.
• W4320155972 startingPage "8" @default.
• W4320155972 abstract "Activation of receptor and nonreceptor tyrosyne kinases (TK) is detected in a broad spectrum of human malignancies, including soft tissue sarcomas (STS) and osteosarcomas (OS) and in some cases correlates with poor prognosis and clinical outcomes. Despite the topoisomerase II inhibitor doxorubicin is broadly used for treatment of STS and OC as mono- and as a component of the combined chemotherapeutic regimens, rapid development of tumor resistance to doxorubicin is considered to be most significant factor of poor prognosis and bad clinical outcome, especially for the patients with metastatic and reccurent forms of disease. This, in turn, remains a driving force to develop novel effective approaches to increase sensitivity of tumor cells to this chemotherapeutic agent and overcome drug resistance. Our current data illustates activation of c-Met-, FGFR-, AKT-, и МAPK-kinases in OS cells, whereas inhibition of their activities with corresponding TK inhibitors (TKIs) (crizotinib, BGJ398, MK-2206, and U0126, respectively) enhances cytotoxic activity of doxorubicin against OS cells. The most prominent synergism between doxorubicin and TKIs inhibitors was found for AKT inhibitor MK- 2206. We found that MK-2206 significantly enhanced sensitivity of OS cells to doxorubicin and induced their apoptosis. Thus, activation of AKT signaling in OS might be an attractive therapeutic target to increase OS sensitivy to chemotherapeutic agents, in particular, doxorubicin. This in turn provide the molecular basis for the effective further use of the combined (AKT- and topoisomerase II inhibitors) therapy for patinets with OS." @default.
• W4320155972 created "2023-02-13" @default.
• W4320155972 creator A5051788868 @default.
• W4320155972 creator A5069373680 @default.
• W4320155972 date "2022-01-01" @default.
• W4320155972 modified "2023-10-07" @default.
• W4320155972 title "AKT INHIBITOR POTENTIATES CYTOTOXIC ACTIVITY OF DOXORUBICIN IN OSTEOSARCOMA CELLS IN VITRO" @default.
• W4320155972 doi "https://doi.org/10.32000/2078-1466-2022-3-8-20" @default.
• W4320155972 hasPublicationYear "2022" @default.
• W4320155972 type Work @default.
• W4320155972 citedByCount "0" @default.
• W4320155972 crossrefType "journal-article" @default.
• W4320155972 hasAuthorship W4320155972A5051788868 @default.
• W4320155972 hasAuthorship W4320155972A5069373680 @default.
• W4320155972 hasConcept C126322002 @default.
• W4320155972 hasConcept C147897179 @default.
• W4320155972 hasConcept C154317977 @default.
• W4320155972 hasConcept C184235292 @default.
• W4320155972 hasConcept C185592680 @default.
• W4320155972 hasConcept C190283241 @default.
• W4320155972 hasConcept C202751555 @default.
• W4320155972 hasConcept C2776694085 @default.
• W4320155972 hasConcept C2781303535 @default.
• W4320155972 hasConcept C502942594 @default.
• W4320155972 hasConcept C55493867 @default.
• W4320155972 hasConcept C71924100 @default.
• W4320155972 hasConcept C75217442 @default.
• W4320155972 hasConcept C98274493 @default.
• W4320155972 hasConceptScore W4320155972C126322002 @default.
• W4320155972 hasConceptScore W4320155972C147897179 @default.
• W4320155972 hasConceptScore W4320155972C154317977 @default.
• W4320155972 hasConceptScore W4320155972C184235292 @default.
• W4320155972 hasConceptScore W4320155972C185592680 @default.
• W4320155972 hasConceptScore W4320155972C190283241 @default.
• W4320155972 hasConceptScore W4320155972C202751555 @default.
• W4320155972 hasConceptScore W4320155972C2776694085 @default.
• W4320155972 hasConceptScore W4320155972C2781303535 @default.
• W4320155972 hasConceptScore W4320155972C502942594 @default.
• W4320155972 hasConceptScore W4320155972C55493867 @default.
• W4320155972 hasConceptScore W4320155972C71924100 @default.
• W4320155972 hasConceptScore W4320155972C75217442 @default.
• W4320155972 hasConceptScore W4320155972C98274493 @default.
• W4320155972 hasIssue "3" @default.
• W4320155972 hasLocation W43201559721 @default.
• W4320155972 hasOpenAccess W4320155972 @default.
• W4320155972 hasPrimaryLocation W43201559721 @default.
• W4320155972 hasRelatedWork W2090546918 @default.
• W4320155972 hasRelatedWork W2157339917 @default.
• W4320155972 hasRelatedWork W2348210391 @default.
• W4320155972 hasRelatedWork W2416964709 @default.
• W4320155972 hasRelatedWork W2964970410 @default.
• W4320155972 hasRelatedWork W2995096195 @default.
• W4320155972 hasRelatedWork W3181092664 @default.
• W4320155972 hasRelatedWork W4213044462 @default.
• W4320155972 hasRelatedWork W4237090850 @default.
• W4320155972 hasRelatedWork W4284891551 @default.
• W4320155972 hasVolume "13" @default.
• W4320155972 isParatext "false" @default.
• W4320155972 isRetracted "false" @default.
• W4320155972 workType "article" @default.