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• W4320165355 abstract "Objective — to study composition of the main phylotypes of the gut microbiota Bacteroidetes, Firmicutes and Actinobacteria and their ratio Firmicutes/Bacteroidetes in patients with non-alcoholic fatty liver disease (NAFLD) against the background of obesity depending on gender and age.Materials and methods. The study included 59 patients with NAFLD against the obesity background (the main group), from them 24 (40.7 %) women and 35 (59.3 %) men aged 43 to 62 years (median 49 years). The body mass index (BMI) was 35.60 (31.80; 39.30) kg/m2. The comparison group included 14 patients with NAFLD: 10 (71.4 %) women and 4 (28.6 %) men aged 36 to 58 years (median 51years) with and without obesity, the BMI 27.30 (27.00; 28.20) kg/m2. The control group consisted of 9 practically healthy volunteers, The groups were age- and gender-matching. All patients underwent an ultrasound examination of the liver and a general clinical laboratory examination, which additionally included measuring the ratio of the phylotype Bacteroidetes, Firmicutes and Actinobacteria in fecal content by real-time polymerase chain reaction with the calculation of the Firmicutes/Bacteroidetes ratio.Results. Significant changes in anthropometric parameters were observed in patients with NAFLD and obesity: an increase in BMI of 30.40 % (p < 0.05) and an increase in waist circumference by 25.00 % (p < 0.05). A decrease in the relative Bacteroidetes content was detected in patients with NAFLD with concomitant obesity and isolated NAFLD (14.74 (6.46; 28.80) % and 16.85 (8.46; 33.33) %, respectively) when compared with the control group (33.3 (8.48; 50.39) %) (H = 2.90, p = 0.23). The highest relative Firmicutes content was determined in patients with NAFLD (52.52 (42.39; 62.88) %) and in patients with comorbid course of NAFLD and obesity (51.35 (37.65; 67.80) %) and decrease in individuals of the main group at 32.97 (22.02; 43.08) %. This dynamics of the indicator was also preserved for the Firmicutes/Bacteroidetes ratio. In control group, the relative Actinobacteria content was 1.73 (1.16; 2.17) %, and in patients with NAFLD — up to 3.98 (1.53; 5.22) %, reaching maximum values in patients with concomitant obesity — 4.40 (2.54; 9.60) %.Conclusions. The ratio of the major intestinal microbiota phylotypes was significantly different in NAFLD patients, in particular in patients with concomitant obesity. In comparison with the group of healthy volunteers, the increase of the relative Actinobacteria content in 2.3 times and Firmicutes in 1.59 times was observed in patients with an isolated NAFLD course; in case of NAFLD and obesity comorbid course, the relative amount the increase was in 2.54 times for Actinobacteria, and in 1.55 times for Firmicutes level." @default.
• W4320165355 created "2023-02-13" @default.
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• W4320165355 date "2019-10-31" @default.
• W4320165355 modified "2023-09-27" @default.
• W4320165355 title "Ratio of the main phylotypes of gut microbiota in patients with non-alcoholic fatty liver disease and obesity" @default.
• W4320165355 doi "https://doi.org/10.30978/mg-2019-5-26" @default.
• W4320165355 hasPublicationYear "2019" @default.
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